Clomipramine hydrochlorideCAS: 17321-77-6
MF: C19H23ClN2•HCl
MW: 351.32
A selective ST, SLC6A2, and DAT inhibitor.

Clomipramine hydrochloride (CAS 17321-77-6)

Clomipramine hydrochloride | CAS 17321-77-6 is rated 5.0 out of 5 by 1.
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Synonym: Anafranil hydrochloride
Application: A selective ST, SLC6A2, and DAT inhibitor
CAS Number: 17321-77-6
Purity: ≥98%
Molecular Weight: 351.32
Molecular Formula: C19H23ClN2•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Clomipramine hydrochloride (Anafranil) is a hydrochloride salt of clomipramine which is an ST (serotonin transporter/SERT), SLC6A2 (norepinephrine transporter/NET), and DAT (dopamine transporter) blocker with Ki of 0.14, 54 and 3 nM, respectively. Clomipramine hydrochloride is a tricyclic antidepressant, a norepinephrine-reuptake inhibitor, and an antiobsessional drug.

Clomipramine hydrochloride is an inhibitor of D2 receptor (Ki = 162 nM), D3 receptor (Ki = 30 nM), AR (α1-adrenergic receptor, Ki = 3.2 nM), α2-adrenergic receptor (Ki = 525 nM), H1 receptor (Ki = 31 nM), mACh receptors (Ki = 37 nM), 5-HT2A receptor (Ki = 36 nM), 5-HT2C receptor (Ki = 65 nM), 5-HT3 receptor (Ki = 85 nM), 5-HT6 receptor (Ki = 54 nM), 5-HT7 receptor (Ki = 127 nM), D1 receptor (Ki = 219 nM).


References

1. McTavish, D. and Benfield, P. 1990. Drugs. 39: 136-153. PMID: 2178909
2. Ortiz, J. and Artigas, F. 1992. Br. J. Pharmacol. 105: 941-946. PMID: 1387022
3. Owens, M.J., et al. 1997. J. Pharmacol. Exp. Ther. 283: 1305-1322. PMID: 9400006

Physical State :
Solid
Solubility :
Soluble in water (125 mg/ml), ethanol (70 mg/ml at 25° C), chloroform (1:3), DMSO (70 mg/ml at 25° C), and dilute aqueous acid.
Storage :
Store at room temperature
Melting Point :
189-192° C
Refractive Index :
n20D 1.58 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 5.01 µM; Mitochondrial import inner membrane translocase subunit TIM10: IC50 = 37.8 µM (Saccharomyces cerevisiae S288c)
Ki Data :
ST: Ki= 0.14 nM; DAT: Ki= 3 nM; α1-adrenergic receptor : Ki= 3.2 nM; H1 receptor: Ki= 31 nM; 5-HT2A receptor: Ki= 36 nM; SLC6A2: Ki= 54 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
HN9055000
PubChem CID :
68539
Merck Index :
14: 2387
MDL Number :
MFCD00069234
EC Number :
241-344-3
SMILES :
CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl.Cl

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Certificate of Analysis

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Clomipramine hydrochloride  Product Citations

See how others have used Clomipramine hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 27681341  Alves, V. et al. 2017. J Anal Toxicol. 41: 45-53.

PMID: # 26189207  Alves, V. et al. 2015. Journal of chromatography. A. 1408: 30-40.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Kim Kim, JW. et al. (PubMed 22992375) found that administration of the selective ST, SLC6A2, and DAT inhibitor Clomipramine to neonatal mice alters stress response behavior and serotonergic gene expressions in adult mice. -SCBT Publication Review
Date published: 2015-03-25
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