Clofilium tosylateA K+ channel blocker

Clofilium tosylate (CAS 92953-10-1)

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Synonym: 4-Chloro-N,N-diethyl-N-heptylbenzenebutanaminium . tosylate
Application: A K+ channel blocker
CAS Number: 92953-10-1
Molecular Weight: 510.2
Molecular Formula: C21H37ClN•C7H7O3S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Clofilium tosylate is a quaternary ammonium compound that acts as potassium channel blocker. Clofilium is a class III agent. Studies report that in a concentration dependent manner, Clofilium tosylate weakens the contraction induced by Galanin.


References

1. Arena, J.P. and Kass, R.S. 1988. Mol. Pharmacol. 34(1): 60-66. PMID: 2455861
2. Gough, W.B. and el-Sherif, N. 1989. Cardiovasc. Res. 23(6): 554-559. PMID: 2590928
3. Korolkiewicz, R. et al. 1997. Pharmacol. Res. 36(2): 147-151. PMID: 9344644

Physical State :
Solid
Solubility :
Soluble in water, methanol, and DMSO.
Storage :
Store at room temperature
Melting Point :
98-99° C
IC50 :
HERG: IC50 = 2 nM (human)
Ki Data :
HERG: Ki= 0.4 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CY9040870
MDL Number :
MFCD00069233

Download SDS (MSDS)

Certificate of Analysis

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