ClofibrateA biochemical that induces cytochrome P450 IVA1 and IVA3

Clofibrate (CAS 637-07-0)

Clofibrate | CAS 637-07-0 is rated 5.0 out of 5 by 1.
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Application: A biochemical that induces cytochrome P450 IVA1 and IVA3
CAS Number: 637-07-0
Purity: ≥99%
Molecular Weight: 242.70
Molecular Formula: C12H15ClO3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Clofibrate is a ligand agonist for PPARα (peroxisome proliferator-activated receptor α), or an inducer of cytochromes P450's CYP4A1 and CYP4A3. In studies utilizing rats treated with Clofibrate, cytochromes CYP4A1 and CYP4A3 are reported to be expressed in the liver. Further studies of CYP4A1 and CYP4A3 expression in rat liver indicated that these enzymes are able to catalyze oxidation of fatty acids and prostaglandins. Also offered as a deuterium-labelled compound, Clofibrate-d4 (sc-217930)


References

1. Aoyama, T., et al. 1990. J. Lipid Res. 3: 1477-1482. PMID: 2280187
2. Brass, E.P. and Ruff, L.J. 1991. J. Pharmacol. Exp. Ther. 257: 1034-1038. PMID: 2046019
3. Yan, J., et al. 2010. Biochem. Cell Biol. 88: 957-967. PMID: 21102658

Appearance :
Oil
Physical State :
Liquid
Solubility :
Soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), acetone, chloroform, ether, hexane, DMF (>50 mg/ml), and ethanol:PBS (1:6, pH 7.2) (0.1 mg/ml). Insoluble in water.
Storage :
Store at room temperature
Boiling Point :
154-156° C at 20 mmHg
Density :
1.14 g/mL at 25° C
Refractive Index :
n20D 1.5
IC50 :
microsomal lipid peroxidation: IC50 = >1 µg/ml (rat); PPARα: EC5050 = 50 µM (mouse); PPARα: EC5050 = 55 µM (human); PPARγ: EC5050 = 500 µM; PPARδ: EC5050 = > 100 µM
Ki Data :
Fatty acid-binding protein, liver: Ki= 6.92 µM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UE9480000
PubChem CID :
2796
Merck Index :
14: 2377
MDL Number :
MFCD00000615
EC Number :
211-277-4
Beilstein Registry :
1913459
SMILES :
CCOC(=O)C(C)(C)OC1=CC=C(C=C1)Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Yan et al Yan et al. (PubMed ID 21102658) found that clofibrate enhanced L-FABP gene transcription and mRNA stability in hepatoma cells. -SCBT Publication Review
Date published: 2015-02-04
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