Clofibrate is a ligand agonist for PPARα (peroxisome proliferator-activated receptor α), or an inducer of cytochromes P450's CYP4A1 and CYP4A3. In studies utilizing rats treated with Clofibrate, cytochromes CYP4A1 and CYP4A3 are reported to be expressed in the liver. Further studies of CYP4A1 and CYP4A3 expression in rat liver indicated that these enzymes are able to catalyze oxidation of fatty acids and prostaglandins. Also offered as a deuterium-labelled compound, Clofibrate-d4 (sc-217930)
1. Aoyama, T., et al. 1990. J. Lipid Res. 3: 1477-1482. PMID: 2280187 2. Brass, E.P. and Ruff, L.J. 1991. J. Pharmacol. Exp. Ther. 257: 1034-1038. PMID: 2046019 3. Yan, J., et al. 2010. Biochem. Cell Biol. 88: 957-967. PMID: 21102658
Soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), acetone, chloroform, ether, hexane, DMF (>50 mg/ml), and ethanol:PBS (1:6, pH 7.2) (0.1 mg/ml). Insoluble in water.
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