Clofarabine

Clofarabine (CAS 123318-82-1)

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Application: A ribonucleotide reductase and DNA polymerase inhibitor
CAS Number: 123318-82-1
Purity: ≥99%
Molecular Weight: 303.7
Molecular Formula: C10H11ClFN5O3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Clofarabine is a purine nucleoside analogue that is a lipophilic derivative of 2-Chloro-2'-deoxyadenosine (sc-202399). The advantage to using this compound compared to 2-Chloro-2'-deoxyadenosine is the increased stability of the acid. Studies suggest that Clofarabine contains the best qualities of Fludarabine (sc-204755) and 2-Chloro-2'-deoxyadenosine, with increased resistance to deamination and phosphorolysis. The compound functions by inhibiting intracellular ribonucleotide reductase and DNA polymerase, which suppresses DNA replication. Furthermore, Clofarabine displays greater affinity towards dCK (deoxycytidine kinase, dCyd), an enzyme essential in nucleoside phosphorylation.


References

1. Ghanem, H., et al. 2010. Expert Rev Hematol. 3: 15-22. PMID: 21082931

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (10 mM), DMSO (61 mg/mL), and ethanol (10 mM).
Storage :
Store at -20° C
Melting Point :
230-233° C
Boiling Point :
599.52° C at 760 mmHg (Predicted)
Density :
2.12 g/cm3 (Predicted)
Refractive Index :
n20D 1.84 (Predicted)
IC50 :
Ribonucleotide reductase: IC50 = 65 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
UD7473000
Transport :
UN 2811, Class 6.1, Packing group II
PubChem CID :
119182
Merck Index :
14: 2372
MDL Number :
MFCD00871077
SMILES :
C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)F)N=C(N=C2N)Cl

Download SDS (MSDS)

Certificate of Analysis

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