Clinafloxacin is a fluoroquinolone that inhibits both Topo II (DNA gyrase)and topoisomerase IV dually in Streptococcus pneumoniae. The compound has a broad-spectrum activity against gram-negative and gram-positive bacteria, aerobes and anaerobes. Studies comparing the inhibitory effects of the fluoroquinolones: clinafloxacin, trovafloxacin, sparfloxacin (sc-202343), and ciprofloxacin (sc-29064) demonstrated clinafloxacin having the greatest inhibition of Topo II (DNA gyrase) and topoisomerase IV.
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