CL 316243 disodium saltA β3-AR agonist

CL 316243 disodium salt (CAS 151126-84-0)

CL 316243 disodium salt | CAS 151126-84-0 is rated 5.0 out of 5 by 2.
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Synonym: 5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt
Application: A β3-AR agonist
CAS Number: 151126-84-0
Purity: ≥98%
Molecular Weight: 465.79
Molecular Formula: C20H18ClNO72Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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CL 316243 disodium salt is a highly selective β3-AR adrenoceptor agonist. The β3-AR is part of a family of adrenergic receptors (or adrenoreceptors), a common G-protein coupled receptor. β3-ARs are primarily located in the small intestine, adipose tissue, and vascular endothelium. CL 316243 disodium salt has been shown to cause increases in brown adipose tissue thermogenesis and metabolic rate as well as decreases in blood insulin and glucose levels.


References

1. Liu, X., et al. 1998. Am. J. Physiol. 274: R1212-R1219. PMID: 9644032
2. Woods, M., et al. 2001. J. Urol. 166: 1142-1147. PMID: 11490313
3. Pedzinska-Betiuk, A., et al. 2008. J. Physiol. Pharmacol. 59: 43-54. PMID: 19261970

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (100 mM).
Storage :
Desiccate at -20° C
Melting Point :
>300° C
Refractive Index :
n20D ~1.64 (Predicted)
IC50 :
β3-AR : EC5050 = 3 nM; β2-AR : IC50 = 9.77 µM (rat); β1-AR : IC50 = 30 µM (rat)
Ki Data :
β3-AR : Ki= 20 µM (human); β2-AR : Ki= 79.2 µM (human); β1-AR : Ki= 100 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5312115
SMILES :
CC(CC1=CC2=C(C=C1)OC(O2)(C(=O)[O-])C(=O)[O-])NCC(C3=CC(=CC=C3)Cl)O.[Na+].[Na+]

Download SDS (MSDS)

Certificate of Analysis

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CL 316243 disodium salt  Product Citations

See how others have used CL 316243 disodium salt. Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 31439668  2019. J. Biol. Chem.

PMID: # 29264745  2018. Inflammation. 41: 626-642.

PMID: # 29031719  Dai, L.|Bhargava, P.|Stanya, KJ.|Alexander, RK.|Liou, YH.|Jacobi, D.|Knudsen, NH.|Hyde, A.|Gangl, MR.|Liu, S.|Lee, CH.| et al. 2017. Mol Metab. 6: 1186-1197.

PMID: # 27686741  Liang, X. et al. 2016. Sci Rep. 6: 34345.

PMID: # 27045525  Hattori, K. et al. 2016. Nature communications. 7: 11158.

PMID: # 25918248  Danai, LV. et al. 2015. Mol. Cell. Biol. 35: 2356-65.

PMID: # 23235150  Roth Flach, RJ. et al. 2013. J. Biol. Chem. 288: 2882-92.

Citations 1 to 7 of 7 total

Could you please provide about the technical and analytical parameter of CL316243 for using HPLC, such as UV wavelength, mobile phase?

Asked by: Jz28sail
Thank you for your question. The analytical parameters for sc-203895, CL 316243 disodium salt can be found on the Certificate of Analysis (COA). If a COA for the lot you purchased is not available, it may be requested on the SCBT webpage. Please contact Technical Service by phone, (800)-457-3801 option 2, email <scbt@scbt.com>, or by live chat directly on our website, www.scbt.com if you have any further questions.
Answered by: Chemical Support 5
Date published: 2017-04-05

What is the shipping temperature for this product?

Asked by: hawkeye11
This chemical, CL 316243 disodium salt (CAS 151126-84-0), ships ambient.
Answered by: Chemical Support 1
Date published: 2017-03-22
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Rated 5 out of 5 by from Great Product. Used to induce lipolysis. I recently bought this product to induce lipolysis, in-vivo and ex-vivo, in mice.. Worked perfectly. Dissolved very easily. Induced lipolysis at 1mg and 10mg/kg. No problems. Would recommend.
Date published: 2017-01-02
Rated 5 out of 5 by from Feuermann Feuermann, Y. et al. (PubMed 24356587) used CL 316243, a 3-AR agonist, to determine that brown adipose tissue function in mice with an inactivated miR-193b-365-1 locus was normal and expression of genes associated with functional BAT, including Prdm16 and Ucp1, was unaffected. -SCBT Publication Review
Date published: 2015-04-06
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