CL 316243 disodium salt is a highly selective β3-AR adrenoceptor agonist. The β3-AR is part of a family of adrenergic receptors (or adrenoreceptors), a common G-protein coupled receptor. β3-ARs are primarily located in the small intestine, adipose tissue, and vascular endothelium. CL 316243 disodium salt has been shown to cause increases in brown adipose tissue thermogenesis and metabolic rate as well as decreases in blood insulin and glucose levels.
1. Liu, X., et al. 1998. Am. J. Physiol. 274: R1212-R1219. PMID: 9644032 2. Woods, M., et al. 2001. J. Urol. 166: 1142-1147. PMID: 11490313 3. Pedzinska-Betiuk, A., et al. 2008. J. Physiol. Pharmacol. 59: 43-54. PMID: 19261970
Could you please provide about the technical and analytical parameter of CL316243 for using HPLC, such as UV wavelength, mobile phase?
Asked by: Jz28sail
Thank you for your question. The analytical parameters for sc-203895, CL 316243 disodium salt can be found on the Certificate of Analysis (COA). If a COA for the lot you purchased is not available, it may be requested on the SCBT webpage. Please contact Technical Service by phone, (800)-457-3801 option 2, email <email@example.com>, or by live chat directly on our website, www.scbt.com if you have any further questions.
Answered by: Chemical Support 5
Date published: 2017-04-05
What is the shipping temperature for this product?
Asked by: hawkeye11
This chemical, CL 316243 disodium salt (CAS 151126-84-0), ships ambient.
Rated 5 out of
Great Product. Used to induce lipolysis.I recently bought this product to induce lipolysis, in-vivo and ex-vivo, in mice.. Worked perfectly. Dissolved very easily. Induced lipolysis at 1mg and 10mg/kg. No problems. Would recommend.
Date published: 2017-01-02
Rated 5 out of
FeuermannFeuermann, Y. et al. (PubMed 24356587) used CL 316243, a 3-AR agonist, to determine that brown adipose tissue function in mice with an inactivated miR-193b-365-1 locus was normal and expression of genes associated with functional BAT, including Prdm16 and Ucp1, was unaffected. -SCBT Publication Review
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