Anti-Cks1/2 Antibody (F-12) is a mouse monoclonal IgG1 (kappa light chain) Cks1/2 antibody provided at 200 µg/ml
raised against amino acids 1-79 representing full length Cks1 of human origin
Anti-Cks1/2 Antibody (F-12) is recommended for detection of Cks1 and Cks2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
Anti-Cks1/2 Antibody (F-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of Cks1/2 (F-12): sc-376663.
At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Cks1/2 Antibody (F-12). This work is in progress.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
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SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Cks1/2 Antibody (F-12) is a high quality monoclonal Cks1/2 antibody (also designated Cks1/2 antibody) suitable for the detection of the Cks1/2 protein of mouse, rat and human origin. Cks1/2 Antibody (F-12) is available as both the non-conjugated anti-Cks1/2 antibody form, as well as multiple conjugated forms of anti-Cks1/2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The Cdc2 p34-cyclin B complex plays a critical role in the cell cycle by regulating the G2 to M phase transition. Also referred to as M phase promoting factor or MPF, this complex is a required component of the cell cycle machinery and is necessary for cell entry into mitosis. The Cdc28 protein represents the S. cerevisiae counterpart of human Cdc2 p34 and has been found complexed to a regulatory protein, termed p13suc 1, in addition to cyclin B. Two proteins associated with the Cdc2 p34-cyclin B complex are called Cks1 and Cks2. Null mutations in the p13suc 1 and Cks1 genes result in the arrest of the cell cycle at either the G1 or G2 phase, suggesting that the proteins may also regulate the activity of cyclin dependent kinases that act at critical points early in the cell cycle. Cks2 (cyclin-dependent kinases regulatory subunit 2) is a 79 amino acid protein that binds to the catalytic subunit of cyclin-dependent kinases, such as those in the Cdc2 p34-cyclin B complex. An essential component of this cyclin/cyclin-dependent kinase complex, Cks2 contributes to cell cycle control and is able to form a homohexamer that can bind up to 6 subunits. Without proper activity of Cks2, the first metaphase/anaphase transition of meiosis cannot occur.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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