CKI-7 dihydrochloride CAS: 1177141-67-1
MF: C11H12ClN3O2S•2HCl
MW: 358.67
An inhibitor of CK1, SGK, S6K1 and MSK1.

CKI-7 dihydrochloride (CAS 1177141-67-1)

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Alternate Names: N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulphonamide dihydrochloride
Application: CKI-7 dihydrochloride is an inhibitor of CK1, SGK, p70 S6 Kinase (S6K1) and MSK1.
CAS Number: 1177141-67-1
Purity: ≥98%
Molecular Weight: 358.67
Molecular Formula: C11H12ClN3O2S•2HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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CKI-7 dihydrochloride is a CK1 inhibitor which also inhibits SGK, S6K1 and MSK1. It inhibits SGK as potently as CK1.


References

Rena, G., et al. , D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO J. Rep. 5, 60-65, (2004)

Physical State :
Solid
Solubility :
Soluble in water: >5 mg/mL
Storage :
Desiccate at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
SMILES :
C1=CC(=C2C=CN=CC2=C1S(=O)(=O)NCCN)Cl.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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CKI-7 dihydrochloride (CAS 1177141-67-1)  Product Citations

See how others have used CKI-7 dihydrochloride (CAS 1177141-67-1). Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 31363912  J. Mol. Neurosci. 69: 597-607.

PMID: # 28285945  Int. J. Dev. Neurosci. 59: 21-30.

PMID: # 32693359  Int. Immunopharmacol. 106808.

PMID: # 32324266  J. Cell. Physiol.

PMID: # 32416294  Int. J. Biol. Macromol. 159: 154-173.

Citations 1 to 5 of 5 total
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