Citric Acid MonohydrateCAS: 5949-29-1
MF: C6H8O7•H2O
MW: 210.14
A useful buffer component for antigen and epitope unmasking.

Citric Acid Monohydrate (CAS 5949-29-1)

Citric Acid Monohydrate | CAS 5949-29-1 is rated 5.0 out of 5 by 1.
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Synonym: 2-Hydroxy-1,2,3-propanetricarboxylic acid monohydrate
Application: A useful buffer component for antigen and epitope unmasking
CAS Number: 5949-29-1
Purity: ≥98%
Molecular Weight: 210.14
Molecular Formula: C6H8O7•H2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Citric Acid Monohydrate is an acidic compound from citrus fruits; as a starting point in the Krebs cycle, citrate is a key intermediate in metabolism. Citric acid is one of a series of compounds responsible for the physiological oxidation of fats, carbohydrates, and proteins to carbon dioxide and water. It has been used to prepare citrate buffer for antigen retrieval of tissue samples. The citrate solution is designed to break protein cross-links, thus unmasking antigens and epitopes in formalin-fixed and paraffin embedded tissue sections, and resulting in enhanced staining intensity of antibodies. Citrate has anticoagulant activity; as a calcium chelator, it forms complexes that disrupt the tendency of blood to clot. May be used to adjust pH and as a sequestering agent for the removal of trace metals.
Additional forms available:
Citric Acid, Anhydrous (sc-211113)
Sodium Citrate, Dihydrate (sc-203383)
Citric Acid Trisodium Salt (sc-214745)
Sodium citrate monobasic (sc-215869)
Sodium citrate tribasic hydrate (sc-236898)
Citrate Concentrated Solution (sc-294091)


References

1. Vandemark, P.J. and Smith, P.F. 1964. J. Bacteriol. 88: 1602-1607. PMID: 14240945
2. Shi, S.R., et al. 1993. J. Histochem. Cytochem. 41: 1599-1604. PMID: 7691930
3. Echezarreta, G., et al. 1997. Sangre. 42: 369-375. PMID: 9424736
4. Uszyński, W., et al. 2007. Folia Histochem. Cytobiol. 45: 33-36. PMID: 17378243

Physical State :
Solid
Solubility :
Soluble in water (59.2 g/100 ml) at 20° C, ethanol, ether, and water (84.0 g/100 ml) at 100° C.
Storage :
Desiccate at room temperature
Density :
1.54 g/cm3 at 20° C
Refractive Index :
n20D 1.36 (lit.)
pK Values :
pKa: pK1: 3.13, pK2: 4.76, pK3: 6.4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
GE7810000
PubChem CID :
22230
Merck Index :
14: 2326
MDL Number :
MFCD00149972
EC Number :
201-069-1
Beilstein Registry :
4018641
SMILES :
C(C(=O)O)C(CC(=O)O)(C(=O)O)O.O

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Certificate of Analysis

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Citric Acid Monohydrate  Product Citations

See how others have used Citric Acid Monohydrate. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 10873093  Vakkala, M. et al. 2000. Clin. Cancer Res. 6: 2408-2416.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Various publications cite the use of Citric Various publications cite the use of Citric Acid Monohydrate as a useful buffer component for antigen and epitope unmasking in formalin-fixed and paraffin embedded tissue sections. It has also been used as a chelating agent and for its anticoagulant properties. -SCBT Publication Review
Date published: 2015-02-14
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