Citalopram, Hydrobromide SaltA selective inhibitor of the 5-hydroxytryptamine transporter

Citalopram, Hydrobromide Salt (CAS 59729-32-7)

Citalopram, Hydrobromide Salt | CAS 59729-32-7 is rated 5.0 out of 5 by 1.
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Application: A selective inhibitor of the 5-hydroxytryptamine transporter
CAS Number: 59729-32-7
Purity: 98%
Molecular Weight: 405.30
Molecular Formula: C20H22BrFN2O
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Citalopram, Hydrobromide Salt is a selective inhibitor of the ST (5-hydroxytryptamine transporter) (serotonin) and therefore is a potent and selective serotonin reuptake inhibitor. Additional studies in indicate that Citalopram may be a weak, allosteric modulator of serotonin in a cross-species chimeric study. Studies also indicate that Citalopram is useful for studying gene expression patterns in circulating lymphocytes. In zebrafish, Citalopram is noted to reduce the frequency of NMDA-induced locomotor rhythm involved in swimming behavior.


References

1. Torres, G.E., et al. 2003. Nat. Rev. Neurosci. 4: 13-25. PMID: 12511858
2. Palotás, A., et al. 2004. Neurochem. Res. 29: 1563-1570. PMID: 15260135
3. Neubauer, H.A., et al. 2006. Mol. Pharmacol. 69: 1242-1250. PMID: 16434615
4. Gabriel, J.P., et al. 2009. J. Neurosci. 29: 10387-10395. PMID: 19692613

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/mL), ethanol (20 mg/mL) and water (4 mg/mL)
Storage :
Store at room temperature
Melting Point :
185-188° C
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
Alpha-1b adrenergic receptor: IC50 = 3.29 µM (rat); Norepinephrine transporter: IC50 = 8.8 µM (rat); Histamine H1 receptor: IC50 = 3.19 µM (human); Serotonin transporter: IC50 = 3.17 nM (rat)
Ki Data :
Serotonin transporter: Ki= 1.5 nM (rat); Serotonin 2c receptor: Ki= 156 nM (human); Dopamine transporter: Ki= 9.27 µM (rat); Alpha-1d adrenergic receptor: Ki= 711 nM (rat); Norepinephrine transporter: Ki= 6.19 µM (human)
pK Values :
pKa: 9.57 (Predicted), pKb: 4.31
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
77995
Merck Index :
14: 2318
MDL Number :
MFCD02101306
EC Number :
261-891-1
Beilstein Registry :
1397373
SMILES :
CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F

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Citalopram, Hydrobromide Salt  Product Citations

See how others have used Citalopram, Hydrobromide Salt. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 26338061  Krasulova, K. et al. 2016. Xenobiotica. 46: 315-24.

PMID: # 24045971  Chae, YJ. et al. 2014. Naunyn Schmiedebergs Arch. Pharmacol. 387: 23-32.

PMID: # 23751335  Writer, JH. et al. 2013. Sci. Total Environ. 461-462: 519-27.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Ranjbar F; et al Ranjbar F; et al. (PubMed ID: 26405453) determined that Citalopram, Hydrobromide Salt does not improve heart rate variability. -SCBT Publication Review
Date published: 2015-02-04
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