Cisplatin CAS: 15663-27-1
MF: H6Cl2N2Pt
MW: 300.05

Cisplatin (CAS 15663-27-1)

Cisplatin | CAS 15663-27-1 is rated 3.7 out of 5 by 3.
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Alternate Names: Cisplatin also known as CDDP; cis-Diammineplatinum(II) dichloride; Cisplatinum; Blastolem; Briplatin; Cisplatyl; Neoplatin; Platinex; cis-Diamminedichloroplatinum(II) Platiblastin; Platosin; Lederplatin; Platinoxan; CDDP; CACP; CPDC; cis-DDP Platamine; Platinol
Application: Cisplatin is a potent platinum-based anti-neoplastic agent which is used as an apoptosis inducer and caspase-3 activator
CAS Number: 15663-27-1
Purity: ≥99%
Molecular Weight: 300.05
Molecular Formula: H6Cl2N2Pt
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
DISCOUNT: Bulk orders of Chemicals totaling $1,000 or more receive a 5% discount.
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Cisplatin is a potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. Cisplatin has also been shown to induce apoptosis through caspase-3 activation and XIAP expression. Cisplatin is shown to cause immunosuppression which is thought to be followed by an increase in the host immune response. Platinated DNA adducts also enhance poisoning of DNA topoisomerase I by camptothecin (sc-200871). Cisplatin was the first member of a class of anticancer drugs, which now include carboplatin (sc-202093) and oxaliplatin (sc-202270), that form DNA adducts resulting in apoptosis; however, these molecules also bind other biological molecules such as enzymes which might play a role in their mechanism of action.


References

1. Bagasra, O., et al. 1985. Cancer Immunol. Immunother. 19: 142-147. PMID: 3157438

2. Bose, R.N. 2002. Mini Rev Med Chem. 2: 103-111. PMID: 12370072

3. Siddik, Z.H. 2003. Oncogene. 22: 7265-7279. PMID: 14576837

4. van Waardenburg, R.C., et al. 2004. J. Biol. Chem. 279: 54502-54509. PMID: 15471886

Appearance :
Powder or crystalline
Physical State :
Solid
Solubility :
Soluble in water (0.25 g/100ml at 25° C), ethanol (<1 mg/ml at 25° C), and DMF (16 mg/ml).
Storage :
Store at room temperature
Melting Point :
270° C
Density :
3.74 g/cm3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
TP2450000
PubChem CID :
Merck Index :
14: 2317
MDL Number :
MFCD00011623
EC Number :
239-733-8
SMILES :
N.N.Cl[Pt+2]Cl

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Cisplatin (CAS 15663-27-1)  Product Citations

See how others have used Cisplatin (CAS 15663-27-1). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 85 total

PMID: # 34963081  Yildirim, C.|Cevik, S.|Yamaner, H.|Orkmez, M.|Eronat, O.|Bozdayı, MA.|Erdem, M.| et al. 2021. J Trace Elem Med Biol. 70: 126917.

PMID: # 33627632  Phatak, V.|von Grabowiecki, Y.|Janus, J.|Officer, L.|Behan, C.|Aschauer, L.|Pinon, L.|Mackay, H.|Zanivan, S.|Norman, JC.|Kelly, M.|Le Quesne, J.|Muller, PAJ.| et al. 2021. Cell Death Dis. 12: 207.

PMID: # 34716381  Karakasheva, TA.|Gabre, JT.|Sachdeva, UM.|Cruz-Acuña, R.|Lin, EW.|DeMarshall, M.|Falk, GW.|Ginsberg, GG.|Yang, Z.|Kim, MM.|Diffenderfer, ES.|Pitarresi, JR.|Li, J.|Muir, AB.|Hamilton, KE.|Nakagawa, H.|Bass, AJ.|Rustgi, AK.| et al. 2021. Sci Rep. 11: 21304.

PMID: # 34088988  Lapidot, M.|Case, AE.|Weisberg, EL.|Meng, C.|Walker, SR.|Garg, S.|Ni, W.|Podar, K.|Hung, YP.|Carrasco, RD.|Knott, A.|Gokhale, PC.|Sharma, S.|Pozhitkov, A.|Kulkarni, P.|Frank, DA.|Salgia, R.|Griffin, JD.|Saladi, SV.|Bueno, R.|Sattler, M.| et al. 2021. Br J Cancer.

PMID: # 34638373  Brulin, B.|Nolan, JC.|Marangon, T.|Kovacevic, M.|Chatelais, M.|Meheust, P.|Abadie, J.|Le Nail, LR.|Rosset, P.|Brennan, MÁ.|Layrolle, P.| et al. 2021. Cancers (Basel). 13:

PMID: # 33368015  Catalán, M.|Rodríguez, C.|Olmedo, I.|Carrasco-Rojas, J.|Rojas, D.|Molina-Berríos, A.|Díaz-Dosque, M.|Jara, JA.| et al. 2021. Adv Exp Med Biol. 1326: 95-109.

PMID: # 33529758  He, S.|Li, G.|Schätzlein, AG.|Humphrey, PA.|Weiss, RM.|Uchegbu, IF.|Martin, DT.| et al. 2021. Cell Signal. 81: 109931.

PMID: # 34497804  Gurer, DC.|Erdogan, İ.|Ahmadov, U.|Basol, M.|Sweef, O.|Cakan-Akdogan, G.|Akgül, B.| et al. 2021. Front Cell Dev Biol. 9: 688855.

PMID: # 34364401  Parma, B.|Ramesh, V.|Gollavilli, PN.|Siddiqui, A.|Pinna, L.|Schwab, A.|Marschall, S.|Zhang, S.|Pilarsky, C.|Napoli, F.|Volante, M.|Urbanczyk, S.|Mielenz, D.|Schrøder, HD.|Stemmler, M.|Wurdak, H.|Ceppi, P.| et al. 2021. J Exp Clin Cancer Res. 40: 248.

PMID: # 33479625  Catalán, M.|Castro-Castillo, V.|Gajardo-de la Fuente, J.|Aguilera, J.|Ferreira, J.|Ramires-Fernandez, R.|Olmedo, I.|Molina-Berríos, A.|Palominos, C.|Valencia, M.|Domínguez, M.|Souto, JA.|Jara, JA.| et al. 2020. RSC Med Chem. 11: 1210-1225.

Citations 1 to 10 of 85 total

what is good solvent? ex) DMSO, 3.D.W

Asked by: ami204
Thank you for your question. Cisplatin (CAS 15663-27-1) sc-200896 is soluble in water (0.25 g/100ml at 25&deg; C), ethanol (&lt;1 mg/ml at 25&deg; C), and DMF (16 mg/ml).
Answered by: Tech Support Europe
Date published: 2019-06-19

If mixed with DMSO how should it be stored? for long term storage?

Asked by: rpdee
Thank you for your question. DMSO is not a recommended solvent for Cisplatin. The divalent platinum has a high affinity for sulfur donor ligands and this will displace the chloride. The use of DMSO as a solvent affects the instability of cisplatin and can affect biological activity. Sundquist, W. I., et al., Inorg. Chem. 26:1524-1528, 1987.
Answered by: Technical Support
Date published: 2019-04-13

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Cisplatin, sc-200896, is in yellow crystalline powder form.
Answered by: Chemical Support 4
Date published: 2018-11-06

Is it HPLC grade?

Asked by: chemsd02
Thank you for your question. Yes, sc-200896 (Cisplatin, CAS 15663-27-1) is HPLC grade.
Answered by: Chemical Support 10
Date published: 2021-05-17

From the website: material is soluble in water at 0.25g/100ml in 25℃. How long can it be stocked? Can it be stable for at least one year? Should I adjust its pH? Thank you!

Asked by: two2igm05
Thank you for your question. Cisplatin, sc-200896, can be stored for 3 years at -20℃ as a powder and for 6 months at -80℃ in solvent.
Answered by: TechService7
Date published: 2016-12-21
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Rated 1 out of 5 by from Dissolving issues Even though it is highly recommended not to dissolve cisplatin in DMSO, it seems that it is the only solvent that it dissolves in. Please recommend solvents that will dissolve cisplatin as water is not appropriate.
Date published: 2021-02-02
Rated 5 out of 5 by from We used this in different human cell lines We used this in different human cell lines and works well for our study.
Date published: 2015-10-06
Rated 5 out of 5 by from Chen Chen, et. al. (PubMed ID 17651689) report that nuclear Trx-1 is required by MCF-7 cells to resist apoptosis when induced by cisplatin. They extrapolate based on this finding that this resistance most likely occurs through the up-regulation of p53 (the anti-apoptotic gene). -SCBT Publication Review
Date published: 2015-04-10
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