CisplatinAn apoptosis inducer and caspase-3 activator

Cisplatin (CAS 15663-27-1)

Cisplatin | CAS 15663-27-1 is rated 5.0 out of 5 by 2.
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Synonym: CDDP; cis-Diammineplatinum(II) dichloride
Application: An apoptosis inducer and caspase-3 activator
CAS Number: 15663-27-1
Purity: ≥99%
Molecular Weight: 300.05
Molecular Formula: Cl2H6N2Pt
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cisplatin is a potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The compound has also been shown to induce apoptosis through caspase-3 activation and XIAP expression. Also shown to cause immunosuppression which is thought to be followed by an increase in the host immune response. Platinated DNA adducts also enhance poisoning of DNA topoisomerase I by camptothecin (sc-200871). Cisplatin was the first member of a class of anticancer drugs, which now include carboplatin (sc-202093) and oxaliplatin (sc-202270), that form DNA adducts resulting in apoptosis; however, these molecules also bind other biological molecules such as enzymes which might play a role in their mechanism of action.


References

1. Bagasra, O., et al. 1985. Cancer Immunol. Immunother. 19: 142-147. PMID: 3157438
2. Bose, R.N. 2002. Mini Rev Med Chem. 2: 103-111. PMID: 12370072
3. Siddik, Z.H. 2003. Oncogene. 22: 7265-7279. PMID: 14576837
4. van Waardenburg, R.C., et al. 2004. J. Biol. Chem. 279: 54502-54509. PMID: 15471886

Appearance :
Powder or crystalline
Physical State :
Solid
Solubility :
Soluble in water (0.25 g/100ml at 25° C), ethanol (<1 mg/ml at 25° C), and DMF (16 mg/ml).
Storage :
Store at room temperature
Melting Point :
270° C
Density :
3.74 g/cm3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
TP2450000
PubChem CID :
441203
Merck Index :
14: 2317
MDL Number :
MFCD00011623
EC Number :
239-733-8
SMILES :
N.N.Cl[Pt+2]Cl

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Cisplatin  Product Citations

See how others have used Cisplatin. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 39 total

PMID: # 31374291  Li, X.|He, S.|Tian, Y.|Weiss, RM.|Martin, DT.| et al. 2019. Cell. Signal. 63: 109381.

PMID: # 29620162  Yang, X. et al. 2018. Int. J. Oncol. 52: 2021-2030.

PMID: # 28567715  Zhao, H. et al. 2017. Cell Oncol (Dordr). 40: 357-365.

PMID: # 29103612  Reitsma, JM. et al. 2017. Cell. 171: 1326-1339.e14.

PMID: # 28339648  Pendergraft, SS. et al. 2017. Biol. Reprod. 96: 720-732.

PMID: # 29267289  Chen, Y. et al. 2017. PLoS ONE. 12: e0187222.

PMID: # 28379541  Aslani, F. et al. 2017. Mol. Hum. Reprod. 23: 370-380.

PMID: # 28265008  Liu, CW. et al. 2017. Mol. Cancer Ther. 16: 1421-1434.

PMID: # 29132253  İnci, D. et al. 2017. J. Biomol. Struct. Dyn. 1-24.

PMID: # 29074567  Gendarme, M. et al. 2017. Mol. Biol. Cell.

Citations 1 to 10 of 39 total

what is good solvent? ex) DMSO, 3.D.W

Asked by: ami204
Thank you for your question. Cisplatin (CAS 15663-27-1) sc-200896 is soluble in water (0.25 g/100ml at 25&deg; C), ethanol (&lt;1 mg/ml at 25&deg; C), and DMF (16 mg/ml).
Answered by: Tech Support Europe
Date published: 2019-06-19

If mixed with DMSO how should it be stored? for long term storage?

Asked by: rpdee
Thank you for your question. DMSO is not a recommended solvent for Cisplatin. The divalent platinum has a high affinity for sulfur donor ligands and this will displace the chloride. The use of DMSO as a solvent affects the instability of cisplatin and can affect biological activity. Sundquist, W. I., et al., Inorg. Chem. 26:1524-1528, 1987.
Answered by: Technical Support
Date published: 2019-04-13

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Cisplatin, sc-200896, is in yellow crystalline powder form.
Answered by: Chemical Support 4
Date published: 2018-11-06

Is it HPLC grade?

Asked by: chemsd02
Thank you for your question. Yes, sc-200896 (Cisplatin, CAS 15663-27-1) is HPLC grade.
Answered by: Chemical Support 10
Date published: 2019-07-02

From the website: material is soluble in water at 0.25g/100ml in 25℃. How long can it be stocked? Can it be stable for at least one year? Should I adjust its pH? Thank you!

Asked by: two2igm05
Thank you for your question. Cisplatin, sc-200896, can be stored for 3 years at -20℃ as a powder and for 6 months at -80℃ in solvent.
Answered by: TechService7
Date published: 2016-12-21
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Rated 5 out of 5 by from We used this in different human cell lines We used this in different human cell lines and works well for our study.
Date published: 2015-10-06
Rated 5 out of 5 by from Chen Chen, et. al. (PubMed ID 17651689) report that nuclear Trx-1 is required by MCF-7 cells to resist apoptosis when induced by cisplatin. They extrapolate based on this finding that this resistance most likely occurs through the up-regulation of p53 (the anti-apoptotic gene). -SCBT Publication Review
Date published: 2015-04-10
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