cis-Resveratrol Solution (in Ethanol)An antioxidant antiproliferative compound shown to inhibit Cox-1

cis-Resveratrol Solution (in Ethanol) (CAS 61434-67-1)

cis-Resveratrol Solution (in Ethanol) | CAS 61434-67-1 is rated 5.0 out of 5 by 1.
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Synonym: (Z)-Resveratrol
Application: An antioxidant antiproliferative compound shown to inhibit Cox-1
CAS Number: 61434-67-1
Purity: >98% (may contain 1-5% trans)
Molecular Weight: 228.20
Molecular Formula: C14H12O3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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cis-Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and antiinflammatory activity. cis-Resveratrol is the double bond isomer of trans-resveratrol, the more often studied and naturally abundant of the two resveratrol isomers. cis-Resveratrol exhibits antioxidant activity in the μM range similar to that observed with trans-resveratrol. It blocks production of reactive oxygen species (ROS) by inhibition of NAD(P)H oxidase (Nox) and also inhibits production of nitric oxide. At a concentration of 100 μM, cis-resveratrol significantly inhibits the expression of genes related to the Rel/NF-κB/Ικβ family, adhesion molecules, and acute-phase proteins in LPS and INF-γ-stimulated murine peritoneal macrophages. cis-Resveratrol inhibits uptake of noradrenaline and 5-HT by synaptosomes from rat brain with IC50 values of 79 and 51 μM, respectively. It also inhibits human MOA-A (monoamine oxidase-A) and MOA-B with IC50 values of 25 and 61μM, respectively, which is similar to, but slightly less effective than, values obtained with trans-resveratrol. cis-Resveratrol is an inhibitor of Cox-1.


References

1 Rotondo, S., Rajtar, G., Manarini, S., et al. Effect of trans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function. Br J Pharmacol 123 1691-1699 (1998). 2 Orallo, F. Comparative studies of the antioxidant effects of cis- and trans-resveratrol. Current Medicinal Chemistry 13 87-98 (2006). 3 Leiro, J., Arranz, J.A., Fraiz, N., et al. Effect of cis-resveratrol on genes involved in nuclear factor kappa B signaling. International Immunopharmacology 5 393-406 (2005). 4 Yáñez, M., Fraiz, N., Cano, E., et al. Inhibitory effects of cis- and trans-resveratrol on noradrenaline and 5-hydroxytryptamine uptake and on monoamine oxidase activity. Biochem Biophys Res Commun 344 688-695 (2006).

Formulation :
A solution in ethanol
Physical State :
Liquid
Solubility :
Soluble in water (<0.1 mg/ml at 25.0° C), DMSO (~50 mg/ml), DMF (~50 mg/ml), ethanol, and methanol.
Storage :
Store at -80° C
Boiling Point :
78° C
Refractive Index :
n20D 1.76 (Predicted)
IC50 :
MAO-A: IC50 = 25 µM (human); CYP19: IC50 = 50 µM (human); Uptake of 5-HT: IC50 = 51 µM (rat brain); MAO-B: IC50 = 61 µM (human); Uptake of noradrenaline: IC50 = 79 µM (rat brain)
pK Values :
pKa: 9.22 in ethanol (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
1548910
MDL Number :
MFCD09841240
Beilstein Registry :
7204499
SMILES :
C1=CC(=CC=C1/C=C\\C2=CC(=CC(=C2)O)O)O

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Certificate of Analysis

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cis-Resveratrol Solution (in Ethanol)  Product Citations

See how others have used cis-Resveratrol Solution (in Ethanol). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 22774205  2012. J. Biochem. 152: 331-40.

PMID: # 21438545  Stark, T. et al. 2011. Anal. Chem. 83: 3398-405.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Furuya Furuya, H. et al. (PubMed 26037299) reported that cis-Resveratrol prevents renal lipotoxicity in high-fat diet-treated mouse model through regulating PPAR- pathway. -SCBT Publication Review
Date published: 2015-01-20
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