Ciprofloxacin HClA DNA gyrase/topoisomerase-targeting antibiotic often used in cell culture

Ciprofloxacin HCl (CAS 93107-08-5)

Ciprofloxacin HCl | CAS 93107-08-5 is rated 5.0 out of 5 by 1.
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Synonym: 1-cyclopropyl-6-fluror-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid hydrochloride
Application: A DNA gyrase/topoisomerase-targeting antibiotic often used in cell culture
CAS Number: 93107-08-5
Purity: ≥98%
Molecular Weight: 367.80
Molecular Formula: C17H18FN3O3•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ciprofloxacin HCl is a highly active fluoroquinoline antibiotic effective against a broad spectrum of bacteria and mycoplasma with few known resistant strains. Ciprofloxacin HCl targets gyrases and topoisomerases inhibiting DNA unwinding. Effective at low concentrations (10 μg/ml) and can effectively eradicate mycoplasma in as little as 12 days. Ciprofloxacin has been used as a plant fungicide and is an analog of Nalidixic Acid. Ciprofloxacin HCl is an inhibitor of Topo II.


References

1. Schmitt, K., et al. 1988. J. Immunol. Methods. 109: 17-25.PMID: 3282011
2. Wolfson, J.S., et al. 1985. Antimicrob. Agents Chemother. 28: 581-586. PMID: 3000292
3. Hooper, D.C. 2001. Emerg Infect Dis, 7: 337–341. PMID: 11294736

Usage :
Powder should be prepared in water or buffered media. To prepare a stock solution add the appropriate amount of powder to distilled deionized water while mixing. Adding water directly to the powder could result in insoluble mixtures that cannot be filtered without losing potency. After ensuring that the mixture is completely solubilized, filter sterilize. If desired, the pH may be adjusted. Concentration is suggested 5μg - 25 μg/mL with 10μg/mL most often utilized.
Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water, and 0.1 M NaOH.
Storage :
Store at room temperature
Melting Point :
311-320° C
IC50 :
DNA topoisomerase II beta: IC50 = 0.2 ug.mL-1 (human)
pK Values :
pKa: 6.43 (Predicted), pKb: 8.68 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
62999
Merck Index :
14: 2314
MDL Number :
MFCD00242856
SMILES :
C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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Ciprofloxacin HCl  Product Citations

See how others have used Ciprofloxacin HCl. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 16 total

PMID: # 31451506  Caton, E.|Nenortas, E.|Bakshi, RP.|Shapiro, TA.| et al. 2019. Antimicrob. Agents Chemother.

PMID: # 26064137  Heger, Z. et al. 2015. Electrophoresis. 36: 1256-64.

PMID: # 25690342  Ito, N. et al. 2015. Pharm. Res. 32: 2527-37.

PMID: # 26110969  Dai, J. et al. 2015. Biotechnol J. 10: 1783-91.

PMID: # 25881748  Tang Girdwood, SC. et al. 2015. Biochem. Pharmacol. 95: 227-37.

PMID: # 25105482  Perucca, P. et al. 2014. J. Photochem. Photobiol. B, Biol. 140: 57-68.

PMID: # 19048100  Brown, JN. et al. 2008. PLoS ONE. 3: -.

PMID: # 17287398  Christov, C. et al. 2007. Mol. Biol. Cell. 18: 1397-1409.

PMID: # 18006661  Funderburg, N. et al. 2007. Proc. Natl. Acad. Sci. U.S.A. 104: 18631-18635.

PMID: # 16914728  Shah, OJ. et al. 2006. Mol. Cell. Biol. 26: 6425-6434.

Citations 1 to 10 of 16 total

We order ciprofloxacin HCl with catalog number SC-29064. Your storage recommendation for antibiotic is room temperature. Is it fine to store ciprofloxacin HCl at 2 - 8 C or is material compromised if stored in the refrigerator(2 - 8 C)? Thank you.

Asked by: Johnny2099
Thank you for your inquiry. Given the fact that melting point for sc-29064, Ciprofloxacin HCl monohydrate is over 300°C, it should be good enough to store it on shelf.It's OK if you choose to store this chemical in fridge.For more detailed information about this question, please call us toll-free at (800) 457-3801 option 2, e-mail <scbt@scbt.com>, or use the live chat on our website.
Answered by: Technical Service 11
Date published: 2018-01-12

What is the solubility of this product?

Asked by: hawkeye11
This chemical, Ciprofloxacin HCl (CAS 93107-08-5), is freely soluble in water, optimal pH is 3.0 - 4.5.
Answered by: Chemical Support 1
Date published: 2017-04-04

What is the appearance of the compund?

Asked by: two2igm05
Thank you for your question. Ciprofloxacin HCl, sc-29064, is in white to light yellow crystalline, powder or crystalline powder form.
Answered by: Chemical Support 4
Date published: 2017-03-27

Is this product considered flammable?

Asked by: hawkeye11
Thank you for your question. Ciprofloxacin HCl, sc-29064, is not considered to be flammable, it is an irritant.
Answered by: TechService7
Date published: 2017-01-20

这个产品四度能稳定保存多久?Lot#J0814是哪一年生产的?溶解在0.01M PBS刚开始完全溶解并且澄清,过一会儿就是白色浑浊,是不是产品保存出现了问题?

Asked by: Andy Jiang
感谢您的提问。Ciprofloxacin HCl:sc-29064的推荐储存温度为室温。我们不提供产品的生产日期,但为所有产品提供一年质保。Ciprofloxacin HCl可溶于水或0.1 M NaOH溶液。更多问题,请联系我们的技术支持部门:电话(+86) 021-60936351,邮箱asia@scbio.cn。 Thank you for your question. The recommended storage temperature for Ciprofloxacin HCl: sc-29064 is room temperature. We do not characterize the date of production, however, we do provide a one-year warranty for all of our products. Ciprofloxacin HCl is soluble in water, and 0.1 M NaOH. If you have any further questions, please contact our Technical Services department at (+86) 021-60936351 or asia@scbio.cn.
Answered by: Technical Support 12
Date published: 2016-11-28

Ciprofloxacin HCl 跟Ciprofloxacin有什么区别?溶解性方面区别如何,酸性环境中更好溶解吗?稳定性怎么样?谢谢!

Asked by: Andy Jiang
感谢您的提问。Ciprofloxacin HCl是Ciprofloxacin的盐酸盐。Ciprofloxacin HCl易溶于水,最佳pH 3.0 - 4.5。 Thank you for your question. Ciprofloxacin HCl is ciprofloxacin hydrochloride. Ciprofloxacin HCl is freely soluble in water, optimal pH is 3.0 - 4.5.
Answered by: Technical Support 12
Date published: 2017-07-31
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Rated 5 out of 5 by from Various publications report using ciprofloxacin Various publications report using ciprofloxacin HCl as an antibiotic to pro-actively prevent bacterial contamination in cell culture. -SCBT Publication Review
Date published: 2015-01-26
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