Cinnabarinic AcidA mGlu4 receptor agonist

Cinnabarinic Acid (CAS 606-59-7)

Cinnabarinic Acid | CAS 606-59-7 is rated 5.0 out of 5 by 1.
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Application: A mGlu4 receptor agonist
CAS Number: 606-59-7
Purity: ≥95%
Molecular Weight: 300.22
Molecular Formula: C14H8N2O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cinnabarinic Acid is a red pigmented phenoxazinone derivative that has been shown to posses strong apoptosis-inducing activity in thymocytes. Mechanistic studies show that this compound results in the production of reactive oxygen species (ROS) and causes loss of mitochondrial membrane potential and reduces caspase activation. Additional experiments show that Cinnabarinic Acid is capable of completely inhibiting mitochondrial respiratory control. Cinnabarinic acid is also a mGluR-4 agonist and in studies of transiently transfected HEK 293 cells, Cinnabarinic acid acitvates mGluR-4 and is selective over all other types (mGluR-1, mGluR-2, mGluR-5-8).


References

1. Ogawa, H., et al. 1983. Hoppe-Seyler's Z. Physiol. Chem. 364: 1059-1066. PMID: 6629330
2. Eggert, C., et al. 1995. FEBS Lett. 376: 202-206. PMID: 7498542
3. Nagamura, Y., et al. 1999. Adv. Exp. Med. Biol. 467: 419-423. PMID: 10721084
4. Hiramatsu, R., et al. 2008. J. Cell. Biochem. 103: 42-53. PMID: 17476692

Storage :
Store at 4° C
Melting Point :
>300°C (lit.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
114918
SMILES :
C1=CC(=C2C(=C1)OC3=CC(=O)C(=C(C3=N2)C(=O)O)N)C(=O)O

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Certificate of Analysis

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Rated 5 out of 5 by from Hiramatsu et al Hiramatsu et al. (Pubmed ID 17476692) found that Cinnabarinic Acid caused mouse thymocyte apoptosis by activating ROS generation via caspase activation. -SCBT Publication Review
Date published: 2015-06-18
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