Cinnabarinic Acid is a red pigmented phenoxazinone derivative that has been shown to posses strong apoptosis-inducing activity in thymocytes. Mechanistic studies show that this compound results in the production of reactive oxygen species (ROS) and causes loss of mitochondrial membrane potential and reduces caspase activation. Additional experiments show that Cinnabarinic Acid is capable of completely inhibiting mitochondrial respiratory control. Cinnabarinic acid is also a mGluR-4 agonist and in studies of transiently transfected HEK 293 cells, Cinnabarinic acid acitvates mGluR-4 and is selective over all other types (mGluR-1, mGluR-2, mGluR-5-8).
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