CimetidineAn inhibitor of histamine binding to histamine H2 receptors

Cimetidine (CAS 51481-61-9)

Cimetidine | CAS 51481-61-9 is rated 5.0 out of 5 by 1.
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Synonym: Tagamet; SKF-92334; Tratul; Tametin; Dyspamet; Acinil; 2-cyano-1-methyl-3-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine
Application: An inhibitor of histamine binding to histamine H2 receptors
CAS Number: 51481-61-9
Purity: ≥99%
Molecular Weight: 252.34
Molecular Formula: C10H16N6S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cimetidine is an immunomodulator and a histamine congener. Cimetidine competitively inhibits histamine binding to histamine H2 receptors, and suppresses the growth of several tumors, including gastrointestinal cancer. This compound is an anti-angiogenic agent. Cimetidine is an activator of Nischarin.


References

Hill (1990) Distribution, properties and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 42 45. Ernsberger et al (1992) A second generation of centrally acting hypertensive agents act on putative I1-imidazoline receptors. J.Cardiovasc.Pharmacol. 20 S1. Tsoli et al (1995) The imidazoline I1 receptor agonist, moxonidine, inhibits insulin secretion from isolated rat islets of langerhans. Eur.J.Pharmacol. 284 199. Smit et al (1996) Inverse agonism of histamine H2 antagonists accounts for upregulation of spontaneously active receptors. Proc.Natl.Acad.Sci.USA 93 6802.

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water at 37oC.
Storage :
Store at 4° C
Melting Point :
141-143° C
Boiling Point :
487.97° C at 760 mmHg (Predicted) (tautomer)
Density :
1.27 g/cm3 (Predicted) (tautomer)
Refractive Index :
n20D 1.63 (Predicted)
pK Values :
pKa: 6.8, pKb: 7.07 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
MF0035500
PubChem CID :
2756
Merck Index :
14: 2279
MDL Number :
MFCD00133296
EC Number :
257-232-2
SMILES :
CC1=C(N=CN1)CSCCNC(=NC)NC#N

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Certificate of Analysis

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Cimetidine  Product Citations

See how others have used Cimetidine. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26907376  Halwachs, S. et al. 2016. Placenta. 38: 8-15.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Hu et al Hu et al. (PubMed ID 26346531) showed that the histamine antagonist, Cimetidine, inhibited IL-10 production and restored IL-12 secretion in lipopolysaccharide-treated dendritic cells. -SCBT Publication Review
Date published: 2015-07-10
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