Cimetidine is an immunomodulator and a histamine congener. Cimetidine competitively inhibits histamine binding to histamine H2 receptors, and suppresses the growth of several tumors, including gastrointestinal cancer. This compound is an anti-angiogenic agent. Cimetidine is an activator of Nischarin.
Hill (1990) Distribution, properties and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 42 45. Ernsberger et al (1992) A second generation of centrally acting hypertensive agents act on putative I1-imidazoline receptors. J.Cardiovasc.Pharmacol. 20 S1. Tsoli et al (1995) The imidazoline I1 receptor agonist, moxonidine, inhibits insulin secretion from isolated rat islets of langerhans. Eur.J.Pharmacol. 284 199. Smit et al (1996) Inverse agonism of histamine H2 antagonists accounts for upregulation of spontaneously active receptors. Proc.Natl.Acad.Sci.USA 93 6802.
Soluble in water at 37oC.
Store at 4° C
487.97° C at 760 mmHg (Predicted) (tautomer)
1.27 g/cm3 (Predicted) (tautomer)
n20D 1.63 (Predicted)
pKa: 6.8, pKb: 7.07 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Cimetidine Product Citations
See how others have used Cimetidine. Click on the entry to view the PubMed entry
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Hu et alHu et al. (PubMed ID 26346531) showed that the histamine antagonist, Cimetidine, inhibited IL-10 production and restored IL-12 secretion in lipopolysaccharide-treated dendritic cells. -SCBT Publication Review
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