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CIL-102 | CAS 479077-76-4 | SCBT - Santa Cruz Biotechnology
CIL-102 CAS: 479077-76-4
MF: C19H14N2O2
MW: 302.33
An inhibitor of Tubulin polymerization.

CIL-102 (CAS 479077-76-4)

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Alternate Names: 1-[4-(Furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone
Application: CIL-102 is an inhibitor of Tubulin polymerization
CAS Number: 479077-76-4
Purity: ≥95%
Molecular Weight: 302.33
Molecular Formula: C19H14N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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CIL-102 is a semisynthetic alkaloid derivative, which inhibits cell growth in a wide variety of cancer cell lines in a dose dependent manner. Studies conducted with Immunofluorescence microscopy suggest that CIL-102 can functions to slow down cell growth by binding to Tubulin, inhibiting Tubulin polymerization and disrupting microtubule organization. In addition, cells accumulate in the presence of CIL-102 in G(2)/M phase and sub-G(0)/G(1) phase. CIL-102 causes apoptosis in PC-3 cells via activation of caspase-3 and slows down cell growth by modulating cyclin-dependent kinases.


References

1. Huang, Y.T., et al. 2005. J. Biol. Chem. 280: 2771-2779. PMID: 15536083

Physical State :
Solid
Solubility :
Soluble in DMSO (12 mg/ml).
Storage :
Store at -20° C
Melting Point :
196.39° C (Predicted)
Boiling Point :
~498.5° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.72 (Predicted)
pK Values :
pKb: 0.96 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD08277043
SMILES :
CC(=O)C1=CC=C(C=C1)NC2=C3C=COC3=NC4=CC=CC=C42

Download SDS (MSDS)

Certificate of Analysis

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