CIL-102 (CAS 479077-76-4)

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Alternate Names: 1-[4-(Furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone

Application: CIL-102 is an inhibitor of Tubulin polymerization

CAS Number: 479077-76-4

Purity: ≥95%

Molecular Weight: 302.33

Molecular Formula: C₁₉H₁₄N₂O₂

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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SDS & Certificate of Analysis

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CIL-102 is a semisynthetic alkaloid derivative, which inhibits cell growth in a wide variety of cancer cell lines in a dose dependent manner. Studies conducted with Immunofluorescence microscopy suggest that CIL-102 can functions to slow down cell growth by binding to Tubulin, inhibiting Tubulin polymerization and disrupting microtubule organization. In addition, cells accumulate in the presence of CIL-102 in G(2)/M phase and sub-G(0)/G(1) phase. CIL-102 causes apoptosis in PC-3 cells via activation of caspase-3 and slows down cell growth by modulating cyclin-dependent kinases.

References

1. Huang, Y.T., et al. 2005. J. Biol. Chem. 280: 2771-2779. PMID: 15536083

Physical State :

Solid

Solubility :

Soluble in DMSO (12 mg/ml).

Storage :

Store at -20° C

Melting Point :

196.39° C (Predicted)

Boiling Point :

~498.5° C at 760 mmHg (Predicted)

Density :

~1.3 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.72 (Predicted)

pK Values :

pK_b: 0.96 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WGK Germany :

3

PubChem CID :

404353

MDL Number :

MFCD08277043

SMILES :

CC(=O)C1=CC=C(C=C1)NC2=C3C=COC3=NC4=CC=CC=C42

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Certificate of Analysis

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CIL-102 (CAS 479077-76-4)

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References

Download SDS (MSDS)

Certificate of Analysis