CI 994 is an HDAC (histone deacetylase) inhibitor for HDAC1 (Ki = 0.41 μM), HDAC3 (Ki = 0.75 μM), HDAC6 (Ki >100 μM), and HDAC8 (Ki >100 μM). CI 994 is an inhibitor of HDAC2. It induces apoptosis and mediates G1 cell cycle arrest.
1. Kraker, Alan J., et al., 2003. Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benzamide] in HCT-8 colon carcinoma. Molecular cancer therapeutics. 2(4): 401-8. PMID: 12700284 2. Beckers, Thomas., et al., 2007. Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group. International journal of cancer. Journal international du cancer. 121(5): 1138-48. PMID: 17455259
Soluble in DMSO (100 mM), DMF (~1 mg/ml), and 1:5 solution of DMSO: PBS (pH 7.2) (~0.5 mg/ml).
Store at 4° C
~450.6° C at 760 mmHg (Predicted)
~1.3 g/cm3 (Predicted)
n20D 1.71 (Predicted)
HDAC1: IC50 = 0.57 µM (human); HDAC2: IC50 = 0.9 µM (human); HDAC3: IC50 = 1.2 µM (human); Cytotoxicity against human HCT116 cells: IC50 = 4 µM (human); Antiproliferative activity against human LNCap: IC50 = 7.4 µM (human)
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Rated 5 out of
It is highly recommendedCI994, which used to suppress HDAC3, I used for a month, the effect was very good
Date published: 2016-11-24
Rated 5 out of
Beckers et alBeckers et al. (PubMed ID 17455259) showed that the HDAC inhibitor, CI 994, inhibited cell growth and promoted apoptosis in RKO colon cancer cells via histone H3 hyperacetylation. -SCBT Publication Review
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