CI 994An HDAC1, HDAC3, HDAC6, and HDAC8 inhibitor

CI 994 (CAS 112522-64-2)

CI 994 | CAS 112522-64-2 is rated 5.0 out of 5 by 2.
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Synonym: Acetyldinaline, Tacedinaline; N-acetyldinaline
Application: An HDAC1, HDAC3, HDAC6, and HDAC8 inhibitor
CAS Number: 112522-64-2
Purity: ≥98%
Molecular Weight: 269.3
Molecular Formula: C15H15N3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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CI 994 is an HDAC (histone deacetylase) inhibitor for HDAC1 (Ki = 0.41 μM), HDAC3 (Ki = 0.75 μM), HDAC6 (Ki >100 μM), and HDAC8 (Ki >100 μM). CI 994 is an inhibitor of HDAC2. It induces apoptosis and mediates G1 cell cycle arrest.


References

1. Kraker, Alan J., et al., 2003. Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benzamide] in HCT-8 colon carcinoma. Molecular cancer therapeutics. 2(4): 401-8. PMID: 12700284
2. Beckers, Thomas., et al., 2007. Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group. International journal of cancer. Journal international du cancer. 121(5): 1138-48. PMID: 17455259

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), DMF (~1 mg/ml), and 1:5 solution of DMSO: PBS (pH 7.2) (~0.5 mg/ml).
Storage :
Store at 4° C
Melting Point :
216-221° C
Boiling Point :
~450.6° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.71 (Predicted)
IC50 :
HDAC1: IC50 = 0.57 µM (human); HDAC2: IC50 = 0.9 µM (human); HDAC3: IC50 = 1.2 µM (human); Cytotoxicity against human HCT116 cells: IC50 = 4 µM (human); Antiproliferative activity against human LNCap: IC50 = 7.4 µM (human)
Ki Data :
HDAC1: Ki= 50 nM (human); HDAC2: Ki= 190 nM (human); HDAC3: Ki= 550 nM (human)
pK Values :
pKa: 13.15 (Predicted), pKb: 3.8 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CU8702023
PubChem CID :
2746
MDL Number :
MFCD00866266
SMILES :
CC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC=C2N

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Certificate of Analysis

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CI 994  Product Citations

See how others have used CI 994. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26044852  Castellucci, M. et al. 2015. The Journal of allergy and clinical immunology.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from It is highly recommended CI994, which used to suppress HDAC3, I used for a month, the effect was very good
Date published: 2016-11-24
Rated 5 out of 5 by from Beckers et al Beckers et al. (PubMed ID 17455259) showed that the HDAC inhibitor, CI 994, inhibited cell growth and promoted apoptosis in RKO colon cancer cells via histone H3 hyperacetylation. -SCBT Publication Review
Date published: 2015-04-04
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