CI 988 CAS: 130332-27-3
MF: C35H42N4O6
MW: 614.73
A selective and effective antagonist of CCK-BR.

CI 988 (CAS 130332-27-3)

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Application: CI 988 is a selective and effective antagonist of CCK-BR
CAS Number: 130332-27-3
Purity: >99%
Molecular Weight: 614.73
Molecular Formula: C35H42N4O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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CI-988 is a selective and effective antagonist of CCK-BR (CCK2; CCK-B; cholecystokinin 2) receptors. CCK is a neuroendocrine peptide described to play an important role in cell growth, cell proliferation, and other biological functions. Lung cancer cell studies report that Cl 988 inhibits the proliferation of NCI-H209 cells in vitro and the binding of CCK-8 to NCI-H209 cells. In addition Cl 988 blocks the elevated levels of cytosolic Ca2+ induced by CCK-8. Other CCK-BR inhibitors include L-365,260 (sc-205244).


References

1. Hughes, J., et al. 1990. Proc. Natl. Acad. Sci. U.S.A. 87: 6728-6732. PMID: 1975695
2. Coudoré-Civiale, M.A., et al. 2000. Pain. 88: 15-22. PMID: 11098095
3. Moody, T.W., et al.2001. J. Pharmacol. Exp. Ther. 299: 1154-1160. PMID: 11714907
4. Carrillo, J.., et al. 2009. Anticancer Drugs. 20: 527-533. PMID: 19407653

Physical State :
Solid
Solubility :
Soluble in 100 mM DMSO
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9916995
SMILES :
CC(CC1=CNC2=CC=CC=C21)(C(=O)NCC(C3=CC=CC=C3)NC(=O)CCC(=O)O)NC(=O)OC4C5CC6CC(C5)CC4C6

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Certificate of Analysis

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