CI 976CAS: 114289-47-3
MF: C23H39NO4
MW: 393.57
A trimethoxy fatty acid anilide inhibitor of ACAT/SOAT.

CI 976 (CAS 114289-47-3)

CI 976 | CAS 114289-47-3 is rated 5.0 out of 5 by 1.
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Synonym: 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
Application: A trimethoxy fatty acid anilide inhibitor of ACAT/SOAT
CAS Number: 114289-47-3
Purity: ≥98%
Molecular Weight: 393.57
Molecular Formula: C23H39NO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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CI 976 is a trimethoxy fatty acid anilide inhibitor of liver and intestinal acyl coenzyme A cholesterol acyltransferase (ACAT) and sterol O-acyltransferase (SOAT). Cl 976 lowers non-high density lipoprotein (non-HDL) cholesterol and increases HDL-cholesterol concentrations.


References

1. Sliskovic, D.R., et al. 1991. Trends Pharmacol. Sci. 12: 194-199. PMID: 1862535
2. Krause, B.R., et al. 1993. J. Lipid Res. 34: 279-294. PMID: 8429262

Physical State :
Solid
Solubility :
Soluble in ethanol (50 mM), and DMSO (100 mM). Insoluble in water(<2 mg/ml).
Storage :
Store at 4° C
Melting Point :
214.72° C (Predicted)
Boiling Point :
504.71° C at 760 mmHg (Predicted)
Density :
1.00 g/cm3 (Predicted)
Refractive Index :
n20D 1.50 (Predicted)
IC50 :
SOAT1: IC50 = 73 nM (human); Acyl coenzyme A:cholesterol acyltransferase 1: IC50 = 73 nM (rat); Sterol O-acyltransferase, Soat: IC50 = 110 nM (rat); Foam cell formation: IC50 = 3.8 µM (rat peritoneal macrophages); Golgi-associated LPAT activity: IC50 = 15 µM
pK Values :
pKa: 13.26 (Predicted), pKb: 3.52 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
JR2052000
PubChem CID :
122327
MDL Number :
MFCD00869662
Beilstein Registry :
5831010
SMILES :
CCCCCCCCCCC(C)(C)C(=O)NC1=C(C=C(C=C1OC)OC)OC

Download SDS (MSDS)

Certificate of Analysis

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CI 976  Product Citations

See how others have used CI 976. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 26076361  Sánchez Campos, S. et al. 2015. PloS one. 10: e0130726.

PMID: # 22365411  Kim, Y. et al. 2012. Eur J Med Chem. 50: 311-8.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Baba T; et al Baba T; et al. (PubMed ID: 23378048) determined that CI 976 creates unique membrane structures that increase KIAA0725p membrane binding activity in HeLa cells. -SCBT Publication Review
Date published: 2015-06-25
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