CI 976 is a trimethoxy fatty acid anilide inhibitor of liver and intestinal acyl coenzyme A cholesterol acyltransferase (ACAT) and sterol O-acyltransferase (SOAT). Cl 976 lowers non-high density lipoprotein (non-HDL) cholesterol and increases HDL-cholesterol concentrations.
1. Sliskovic, D.R., et al. 1991. Trends Pharmacol. Sci. 12: 194-199. PMID: 1862535 2. Krause, B.R., et al. 1993. J. Lipid Res. 34: 279-294. PMID: 8429262
Soluble in ethanol (50 mM), and DMSO (100 mM). Insoluble in water(<2 mg/ml).
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Baba T; et alBaba T; et al. (PubMed ID: 23378048) determined that CI 976 creates unique membrane structures that increase KIAA0725p membrane binding activity in HeLa cells. -SCBT Publication Review
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