Chrysomycin AA potent antibacterial, antifungal and antiviral compound

Chrysomycin A (CAS 82196-88-1)

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Application: A potent antibacterial, antifungal and antiviral compound
CAS Number: 82196-88-1
Purity: >99%
Molecular Weight: 508.5
Molecular Formula: C28H28O9
* Refer to Certificate of Analysis for lot specific data (including water content).
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Chrysomycin A is the major analogue in a complex of C-glycoside antitumor actives isolated from Streptomyces sp. Chrysomycin A, with a vinyl group in the 8-position, is the most potent analogue of the complex. It was shown to mediate a unique cross-linking reaction between DNA and histidine H3. Also shown to be an antineoplastic and photosensitizing compound. It is thought to act as an inhibitor of the catalytic activity of human topoisomerase II. Chrysomyin A has a potent antibacterial, antifungal, antiviral and antitumor profile. Exhibits antitumor activity against human cell lines K562, HT29, MCF7, PC6, and MKN28. More recent research on related metabolites, the gilvocarcins, suggests that chrysomycins may act as photoactivated crosslinkers of DNA to histones.


References

1. SrelIitz, F., et al. 1955. J. Bacteriol. 69: 280-283. PMID: 14367272
2. Weiss, U., et al. 1982. J. Antibiot. 35: 1194-1201. PMID: 7142022
3. Lorico, A., et al. 1993. Eur. J. Cancer. 29A: 1985-1991. PMID: 8280493
4. Matsumoto, A., et al. 2000. Cancer Res. 60: 3921-3926. PMID: 10919670

Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol.
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
73468
SMILES :
C[C@@H]1[C@@H]([C@@]([C@H]([C@@H](O1)C2=C3C(=C(C=C2)O)C(=CC4=C3OC(=O)C5=CC(=CC(=C54)OC)C=C)OC)O)(C)O)O

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Certificate of Analysis

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