Cholesterol 3-sulfate sodium saltAn activator of multiple protein kinase C enzymes

Cholesterol 3-sulfate sodium salt (CAS 2864-50-8)

Cholesterol 3-sulfate sodium salt | CAS 2864-50-8 is rated 5.0 out of 5 by 1.
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Synonym: Sodium cholesteryl sulfate
Application: An activator of multiple protein kinase C enzymes
CAS Number: 2864-50-8
Molecular Weight: 488.70
Molecular Formula: C27H45O4S•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cholesterol 3-sulfate sodium salt activates multiple protein kinase C (PKC) iso-enzymes, especially the ε, η and ζ isoforms.


References

1. Ikuta, T., et al., 1994. Cholesterol sulfate, a novel activator for the eta isoform of protein kinase C. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 5(9): 943-7. PMID: 7819131
2. Denning, M F., et al., 1995. Cholesterol sulfate activates multiple protein kinase C isoenzymes and induces granular cell differentiation in cultured murine keratinocytes. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 6(12): 1619-26. PMID: 9019167

Physical State :
Solid
Solubility :
Soluble in methanol.
Storage :
Store at 4° C
Melting Point :
172-175° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
3
PubChem CID :
23679068
MDL Number :
MFCD00079091
Beilstein Registry :
3899884
SMILES :
C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)OS(=O)(=O)[O-])C)C.[Na+]

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Certificate of Analysis

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Rated 5 out of 5 by from Denning Denning, MF. et al. (PubMed 9019167) reported that Cholesterol 3-sulfate activates multiple protein kinase C isoenzymes and induces granular cell differentiation in cultured murine keratinocytes. -SCBT Publication Review
Date published: 2015-01-02
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