CHM-1A potent apoptosis inducer

CHM-1 (CAS 154554-41-3)

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Synonym: 2-(2-fluorophenyl)-6,7-methylenedioxy-2-4-quinolone hydrate, NSC 656158
Application: A potent apoptosis inducer
CAS Number: 154554-41-3
Purity: ≥99%
Molecular Weight: 283.25
Molecular Formula: C16H10FNO3
* Refer to Certificate of Analysis for lot specific data (including water content).
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CHM-1 is a potent, selective antitumor agent in human hepatocellular carcinoma in vitro. CHM-1 induces apoptosis, and it binds tubulin and inhibits tubulin polymerization in vitro. Noted to cause cell cycle arrest at G2/M phase by activation of Cdc kinase activity. Also, CHM-1 exhibits vascular targeting activity through upregulation of p53 and induction of death receptor (DR5)-mediated apoptosis in HUVEC cells. Furthermore reported to induce translocation of apoptosis inducing factor (AIF) from the mitochondria to nucleus.


References

Wang, S.W., et al., , CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo. Mol. Cancer Ther. 2nd ed., 7, 350-360, (2008)

Physical State :
Solid
Solubility :
Solubility: Soluble in DMSO: ≥5 mg/mL
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
375860
MDL Number :
MFCD11114577
SMILES :
C1OC2=C(O1)C=C3C(=C2)C(=O)C=C(N3)C4=CC=CC=C4F

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Certificate of Analysis

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