ChlorothiazideAn inhibitor of carbonic anhydrase

Chlorothiazide (CAS 58-94-6)

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Synonym: 6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Application: An inhibitor of carbonic anhydrase
CAS Number: 58-94-6
Molecular Weight: 295.72
Molecular Formula: C7H6N3ClO4S2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Chlorothiazide is an inhibitor of carbonic anhydrase and is slightly less potent than acetazolamide (sc-214461). This compound has been shown to block reabsorption of sodium and chloride ions.


References

1. Beyer, K.H. 1958. Ann. N.Y. Acad. Sci. 71: 363-379. PMID: 13583792
2. Pitts, R.F., et al. 1958. J. Pharmacol. Exp. Ther. 123: 89-97. PMID: 13550061
3. Beyer, K.H. 1959. Ther Umsch. 16: 2-9. PMID: 13635627

Physical State :
Solid
Solubility :
Soluble in DMF, DMSO (≥59 mg/ml), ethanol (<1 mg/ml), and water (0.27 mg/ml at 30° C).
Storage :
Store at 4° C
Melting Point :
350° C (dec.)
Boiling Point :
608.78° C at 760 mmHg (Predicted) (tautomer)
Density :
2.05 g/cm3
Refractive Index :
n20D 1.80
pK Values :
pKa: 6.85
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
DK9450000
PubChem CID :
2720
Merck Index :
14: 2168
MDL Number :
MFCD00058576
EC Number :
200-404-9
SMILES :
C1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)N=CN2

Download SDS (MSDS)

Certificate of Analysis

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