ChlorambucilA nitrogen bifunctional alkylating agent

Chlorambucil (CAS 305-03-3)

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Synonym: Leukeran; Ambochlorin; Chlorbutin
Application: A nitrogen bifunctional alkylating agent
CAS Number: 305-03-3
Purity: ≥98%
Molecular Weight: 304.21
Molecular Formula: C14H19Cl2NO2
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Chlorambucil is a nitrogen mustard bifunctional alkylating agent. Displays antineoplastic and immunosuppressant effect. Induces apoptosis in chronic lymphocytic leukemia cells.


References

1. Povirk, L.F. and Shuker, D.E. 1994. Mutat. Res. 318(3): 205-226. PMID: 7527485

2. Boldogh, I. et al. 2003. Toxicology. 193(1-2): 137-152. PMID: 14599773

3. Amrein, L. et al. 2007. J. Pharmacol. Exp. Ther. 321(3): 848-855. PMID: 17351105

Physical State :
Solid
Derived From :
Synthetic
Solubility :
Soluble in ether, and ethanol:chloroform:acetone (3:5:4) (warm). Insoluble in water.
Storage :
Store at -20° C
Melting Point :
64° C
Boiling Point :
~460.1° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
pK Values :
pKa: 5.8, pKb: 4.62 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
ES7525000
PubChem CID :
2708
Merck Index :
14: 2073
MDL Number :
MFCD00021783
EC Number :
206-162-0
Beilstein Registry :
999011
SMILES :
C1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl

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Certificate of Analysis

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Chlorambucil  Product Citations

See how others have used Chlorambucil. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 24667756  Negreira, N. et al. 2014. The Science of the total environment. 482-483: 389-98.

PMID: # 24148406  2013. Talanta. 116: 290-9.

Citations 1 to 2 of 2 total

Dear Sir/Madam, I would like to order Chlorambucil CAS № 305-03-3 (package size 1g). Before I make an order I should have an offcial offer from You, which include price for this thing and shipping costs.

Asked by: nataliaptaszynska
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Answered by: SCBT Heidelberg Support
Date published: 2018-12-21
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