CHIR-98014 is a selective and ATP-competitive inhibitor of Glycogen Synthase Kinase 3β(GSK-3β) with Ki values of 0.87 nM. In addition, CHIR-98014 displays 500 to greater than 1000-fold selectivity towards GSK3 than other protein kinases such as cdc2 and erk2. The inhibitory effects of CHIR-98014 are similar for both α and β isoforms of GSK-3.
Soluble in DMSO (4 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and 15% Captisol/citrate vehicle (30 mg/ml at 25 °C).
Store at -20° C
~795.1 °C at 760 mmHg (Predicted)
~1.6 g/cm3 (Predicted)
n20D 1.76 (Predicted)
GSK-3 β: IC50 = 0.58 nM; GSK-3 α: IC50 = 0.65 nM
GSK-3 β: Ki= 0.87 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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