ChidamideAn HDAC inhibitor

Chidamide (CAS 743420-02-2)

Chidamide | CAS 743420-02-2 is rated 5.0 out of 5 by 1.
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Synonym: N-(2-amino-5-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)- 2-propen-1-yl]amino]methyl]-benzamide
Application: An HDAC inhibitor
CAS Number: 743420-02-2
Molecular Weight: 390.41
Molecular Formula: C22H19FN4O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Chidamide is an HDAC (histone deacetylase) inhibitor that increases histone H3 acetylation levels in LoVo and HT29 colon cancer cells at concentrations as low as 4 μM.

Physical State :
Solid
Solubility :
Soluble in DMSO (~20 mg/ml), DMF (~20 mg/ml), and 1: 1 DMSO: PBS(pH 7.2) (~0.5 mg/ml).
Storage :
Store at -20° C
Melting Point :
284.63° C (Predicted)
Boiling Point :
~600.16° C at 760 mmHg (Predicted)
Density :
~1.34 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
53394037
MDL Number :
MFCD18382123
SMILES :
C1=CC(=CN=C1)C=CC(=O)NCC2=CC=C(C=C2)C(=O)NC3=C(C=CC(=C3)F)N

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Xu et al Xu et al. (Pubmed ID 25948203) found that Chidamide inhibited RPMI 8226 cell proliferation and caused cycle arrest of RPMI 8226 cells in G0/G1 phase by upregulating the expression of P21. -SCBT Publication Review
Date published: 2015-02-14
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