Chenodeoxycholic acid, free acidAn apoptosis inducer via PKC-dependent signalling pathway

Chenodeoxycholic acid, free acid (CAS 474-25-9)

Chenodeoxycholic acid, free acid | CAS 474-25-9 is rated 5.0 out of 5 by 1.
  • y_2019, m_9, d_16, h_7
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_278835, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 100ms
  • REVIEWS, PRODUCT
Synonym: Chenodeoxycholate; Chenodiol; CDC
Application: An apoptosis inducer via PKC-dependent signalling pathway
CAS Number: 474-25-9
Purity: ≥95%
Molecular Weight: 392.57
Molecular Formula: C24H40O4
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Chenodeoxycholic Acid, Free Acid and its 7β-isomer ursodeoxycholic acid (sc-204935), are potent (nanomolar affinity) selective inhibitors of DD2 (AKR1C2). These compounds were non-competitive inhibitors of AKR1D1 yielding Ki values of 3.2 μM for chenodeoxycholic acid. This chemical is a hydrophobic primary bile acid, which increases intracellular Ca2+ in rat hepatocyte couplets. Studies indicate that Chenodeoxycholic Acid induces apoptosis through a PKC dependent pathway. It is known that Chenodeoxycholic Acid is essential in the metabolism of cholesterol via activation of nuclear receptors. This bile acid can also bind to BABP with a stoichiometery of 1:2. Alternate studies indicate that chenodeoxycholic acid can inhibit the expression of IL-6 and cell viability in QBC939 cells.


References

1. McNeilly, A.D., et al. 2010. J. Hepatol. 52: 705-711. PMID: 20347173
2. Wang, J., et al. 2010. Zhonghua Wai Ke Za Zhi. 48(: 919-923. PMID: 21055228

Physical State :
Solid
Solubility :
Soluble in ethanol (~20 mg/ml), methanol, acetone, glacial acetic acid, DMF, DMSO, and 1:1 DMF:PBS(pH 7.2) (~0.5 mg/ml). Insoluble in water.
Storage :
Store at -20° C
Melting Point :
165-167° C (lit.)
Boiling Point :
547.15° C at 760 mmHg (Predicted)
Density :
1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
Optical Activity :
α20/D +12°, c = 2 in ethanol
IC50 :
GBM: IC50 = >5000 nM (Homo sapiens); HCT-116 (Colon carcinoma cells): IC50 = >5000 nM (Homo sapiens); Bile acid receptor FXR: EC5050 = 3400 nM (Homo sapiens)
pK Values :
pKa: 4.76
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
FZ1980000
PubChem CID :
10133
Merck Index :
14: 2054
MDL Number :
MFCD00064142
EC Number :
207-481-8
Beilstein Registry :
3219887
SMILES :
CC(CCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 207ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Broeders EP; et al Broeders EP; et al. (PubMed ID: 26235421) determined that Chenodeoxycholic acid activated brown adipose tissue activity in rats. -SCBT Publication Review
Date published: 2015-06-02
  • y_2019, m_9, d_16, h_7
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_278835, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 273ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.