CharybdotoxinA potent and selective inhibitor of the large conductance Ca2+-activated K+ channels

Charybdotoxin (CAS 95751-30-7)

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Application: A potent and selective inhibitor of the large conductance Ca2+-activated K+ channels
CAS Number: 95751-30-7
Purity: >91%
Molecular Weight: 4295.89
Molecular Formula: C176H277N57O55S7
* Refer to Certificate of Analysis for lot specific data (including water content).
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Charybdotoxin is a peptide found in the venom of the scorpion Leiurus quinquestriatus. MaxiK (High, BK) or IK1 (intermediate) conductance calcium-activated and Kv1.3 (voltage-gated channel) inhibitor. A potent and selective blocker of the large conductance Ca2+-activated K+, Slo channels in nanomolar concentrations as well as Kv1.2 (Kd = 14 nM) and Kv1.3 (Kd = 2.6 nM) channels. Present in GH3 anterior pituitary cells and primary bovine aortic smooth muscle cells.


References

1. Miller, C., et al. 1985. Nature. 313: 316-318. PMID: 2578618
2. Price, M., et al. 1989. Proc. Natl. Acad. Sci. U.S.A. 86: 10171-10175. PMID: 2481312
3. MacKinnon, R., et al. 1989. Science. 245: 1382-1385. PMID: 2476850
4. Deutsch, C., et al. 1991. J. Biol. Chem. 266: 3668-3674. PMID: 1704892
5. Grissmer, S., et al. 1994. Mol. Pharmacol. 45: 1227-1234. PMID: 7517498
6. Giménez, J., et al. 1994. Toxicon. 32: 1137-1146. PMID: 7801349

Physical State :
Solid
Derived From :
Synthetic
Solubility :
Soluble in water (1 mg/ml).
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
Merck Index :
14: 2046
MDL Number :
MFCD00146378
SMILES :
CC(C)CC(C(=O)NC(CC1CNCN1)C(=O)NC(CC(=O)N)C(=O)NC(C(C)O)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CS)C(=O)NC(CCSC)C(=O)NC(CC(=O)N)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CS)C(=O)NC(CCCNC(=N)N)C(=O)NC(CS)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CO)C(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)N)NC(=O)C(CS)NC(=O)C(C(C)C)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CS)NC(=O)C(CCC(=O)O)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(C(C)O)NC(=O)C(CS)NC(=O)C(CO)NC(=O)C(C(C)C)NC(=O)C(CC(=O)N)NC(=O)C(C(C)O)NC(=O)C(CC5=CC=CC=C5)NC(=O)C(CCC(=O)O)N

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Charybdotoxin  Product Citations

See how others have used Charybdotoxin. Click on the entry to view the PubMed entry .

Citations 1 to 9 of 9 total

PMID: # 27826078  Landa-Juárez, AY. et al. 2016. Eur. J. Pharmacol. 793: 95-100.

PMID: # 23885063  Wang, Z. et al. 2013. Am. J. Physiol., Cell Physiol. 305: C846-53.

PMID: # 22300281  Hollenhorst, MI. et al. 2012. Br. J. Pharmacol. 166: 1388-402.

PMID: # 7517498  Grissmer, S. et al. 1994. Mol. Pharmacol. 45: 1227-1234.

PMID: # 7801349  Giménez, J. et al. 1994. Toxicon. 32: 1137-1146.

PMID: # 1704892  Deutsch, C. et al. 1991. J. Biol. Chem. 266: 3668-3674.

PMID: # 2481312  Price, M. et al. 1989. Proc. Natl. Acad. Sci. U.S.A. 86: 10171-10175.

PMID: # 2476850  MacKinnon, R. et al. 1989. Science. 245: 1382-1385.

PMID: # 2578618  Miller, C. et al. 1985 Jan 24-30. Nature. 313: 316-318.

Citations 1 to 9 of 9 total
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