CHAPS CAS: 75621-03-3
MF: C32H58N2O7S
MW: 614.87
A non-denaturing, zwitterionic detergent for membrane proteins.

CHAPS (CAS 75621-03-3)

CHAPS | CAS 75621-03-3 is rated 5.0 out of 5 by 1.
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Alternate Names: 3-[(3-cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate; 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulphonate
Application: CHAPS is a non-denaturing, zwitterionic detergent for membrane proteins
CAS Number: 75621-03-3
Purity: ≥99%
Molecular Weight: 614.87
Molecular Formula: C32H58N2O7S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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CHAPS is a non-denaturing, zwitterionic detergent derived from cholic acid. CHAPS is often used as a detergent in the solubilization and purification of membrane proteins for several advantageous reasons. CHAPS detergent is non-denaturing to membrane proteins, can solubilize proteins, disaggregate protein-protein interactions and is electrically neutral. CHAPS is also useful in ion exchange chromatography and isoelectric focusing as it is zwitterionic and does not exhibit a net charge between pH 2 to 12. The critical micelle concentration of CHAPS is 6-10mM.


References

1. Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. U.S.A. 77: 6368-6370. PMID: 6935651
2. Ofri, D., et al. 1992. J. Neurochem. 58: 628-635. PMID: 1309566

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (10 mg/ml).
Storage :
Store at 4° C
Melting Point :
157° C
Density :
1.01 g/cm3 at 20° C
pK Values :
pKa: 1.27
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
Merck Index :
14: 2044
MDL Number :
MFCD00012116

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Certificate of Analysis

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CHAPS (CAS 75621-03-3)  Product Citations

See how others have used CHAPS (CAS 75621-03-3). Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 29395787  Blaza, JN.|Vinothkumar, KR.|Hirst, J.| et al. 2018. Structure. 26: 312-319.e3.

PMID: # 27940020  Bridges, HR.|Mohammed, K.|Harbour, ME.|Hirst, J.| et al. 2017. Biochim Biophys Acta Bioenerg. 1858: 197-207.

PMID: # 24947230  Tan, ML.|Shao, P.|Friedhuber, AM.|van Moorst, M.|Elahy, M.|Indumathy, S.|Dunstan, DE.|Wei, Y.|Dass, CR.| et al. 2014. Biomaterials. 35: 7828-38.

PMID: # 32478334  Cell Rep Med. 1: 100014.

Citations 1 to 4 of 4 total

Hello, is CHAPS products ( sc-29088) animal origin free? Thank you,

Asked by: Plamena Garvin
Thank you for your question. This is not animal origin free. Please contact our Technical Service Department to request additional information about the native source for a specific or recent lot.
Answered by: Technical Support
Date published: 2019-05-28
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Rated 5 out of 5 by from Barnadas Barnadas-Rodr guez R; et al. (PubMed ID: 26244704)CHAPS is a zwitterionic surfactant derived from bile salts, most commonly used in protein purification. -SCBT Publication Review
Date published: 2015-06-05
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