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Chaetomellic acid A is a potent inhibitor of farnesyl transferase in isolated enzyme assays (IC50 = 55nM) but it is inactive in whole cells. Inhibition of farnesyltransferase is selective over geranylgeranyltransferase I and II (IC50 = 92μM and 34μM respectively).
J.B. Gibbs, et al.; J. Biol. Chem. 268, 7617 (1993). F. Tamanoi; Trends Biochem. Sci. 18, 349 (1993).
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