CGS 9343B (CAS 109826-27-9)
Alternate Names:
1,3-Dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a][4,1]- benzoxazepin-4-yl)methyl]-4-piperidinyl]-2H-benzimidazol-2-one maleate
Application:
CGS 9343B is a CaM antagonist that inhibits CaM-stimulated cAMP phosphodiesterase activity
CAS Number:
109826-27-9
Molecular Weight:
544.60
Molecular Formula:
C26H28N4O2•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
CGS 9343B is a CAM (calmodulin) antagonist that inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity.
References
Norman et al (1987) CGS 9343B, a novel, potent, and selective inhibitor of Calmodulin activity. Mol. Pharmacol. 31 535. Neuhaus and Reber (1992) Inhibition of membrane currents and rises of intracellular Ca2+ in PC12 cells by CGS 9343B, a calmodulin inhibitor. Eur.J.Pharmacol. 226 183. Li et al (2003) Calmodulin regulates the transcriptional activity of estrogen receptors. J.Biol.Chem. 278 1195.
Physical State
:
Solid
Solubility
:
Soluble in water (50 mM), DMSO (50 mM), and ethanol (10 mM with gentle warming).
Storage
:
Desiccate at room temperature
Boiling Point
:
778° C at 760 mmHg (Predicted)
Refractive Index
:
n20D 1.69 (Predicted)
IC50
:
Calmodulin-stimulated cAMP phosphodiesterase activity: IC50 = 3.3 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
WGK Germany
:
3
RTECS
:
DE0260000
PubChem CID
:
MDL Number
:
MFCD04113002
SMILES
:
CC1(C2=CC=CN2C3=CC=CC=C3CO1)CN4CCC(CC4)N5C6=CC=CC=C6NC5=O.C(=CC(=O)O)C(=O)O
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Certificate of Analysis
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