CGS 9343B CAS: 109826-27-9
MF: C26H28N4O2•C4H4O4
MW: 544.60
A CaM antagonist that inhibits CaM-stimulated cAMP phosphodiesterase activity.

CGS 9343B (CAS 109826-27-9)

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Alternate Names: 1,3-Dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a][4,1]- benzoxazepin-4-yl)methyl]-4-piperidinyl]-2H-benzimidazol-2-one maleate
Application: CGS 9343B is a CaM antagonist that inhibits CaM-stimulated cAMP phosphodiesterase activity
CAS Number: 109826-27-9
Molecular Weight: 544.60
Molecular Formula: C26H28N4O2•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data (including water content).
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CGS 9343B is a CAM (calmodulin) antagonist that inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity.


References

Norman et al (1987) CGS 9343B, a novel, potent, and selective inhibitor of Calmodulin activity. Mol. Pharmacol. 31 535. Neuhaus and Reber (1992) Inhibition of membrane currents and rises of intracellular Ca2+ in PC12 cells by CGS 9343B, a calmodulin inhibitor. Eur.J.Pharmacol. 226 183. Li et al (2003) Calmodulin regulates the transcriptional activity of estrogen receptors. J.Biol.Chem. 278 1195.

Physical State :
Solid
Solubility :
Soluble in water (50 mM), DMSO (50 mM), and ethanol (10 mM with gentle warming).
Storage :
Desiccate at room temperature
Boiling Point :
778° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
IC50 :
Calmodulin-stimulated cAMP phosphodiesterase activity: IC50 = 3.3 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
WGK Germany :
3
RTECS :
DE0260000
PubChem CID :
MDL Number :
MFCD04113002
SMILES :
CC1(C2=CC=CN2C3=CC=CC=C3CO1)CN4CCC(CC4)N5C6=CC=CC=C6NC5=O.C(=CC(=O)O)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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