CGS 21680 HydrochlorideA selective Adenosine A2A-R agonist

CGS 21680 Hydrochloride (CAS 124431-80-7)

CGS 21680 Hydrochloride | CAS 124431-80-7 is rated 5.0 out of 5 by 1.
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Synonym: 2-p-(2-Carboxyethyl)phenethylamino-5′-N-ethylcarboxamidoadenosine hydrochloride
Application: A selective Adenosine A2A-R agonist
CAS Number: 124431-80-7
Molecular Weight: 535.98
Molecular Formula: C23H29N7O6•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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CGS 21680 Hydrochloride is a selective Adenosine A2A-R agonist.


References

Baggiolini, M., et al.: J. Clin. Invest., 84, 1045 (1989), Kainoh, M., et al.: Biochem. Pharmacol., 39, 477 (1990), Bouma, M., et al.: J. Immunol., 153, 4159 (1994), Ollivier, V., et al.: J. Biol. Chem., 271, 20828 (1996), Jordan, J., et al.: J. Pharmacol. Exp. Ther., 280, 301 (1997).

Physical State :
Solid
Solubility :
Soluble in DMSO (107 mg/ml at 25° C), water (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
Storage :
Store at 4° C
Melting Point :
204-206° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10256643
SMILES :
CCNC(=O)[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C2N=C(N=C3N)NCCC4=CC=C(C=C4)CCC(=O)O)O)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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CGS 21680 Hydrochloride  Product Citations

See how others have used CGS 21680 Hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 31409652  2019. Biochem. J. 476: 2371-2391.

PMID: # 28438638  Ansari, MA. et al. 2017. Cell. Signal. 36: 14-24.

PMID: # 23995793  Wolff, F. et al. 2013. Oncogene. 32: 5574-81.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Arasa Arasa, J. et al. (PubMed 24889129) reported that the topical application of the adenosine A2A receptor agonist CGS 21680 prevents phorbol-induced epidermal hyperplasia and inflammation in mice. -SCBT Publication Review
Date published: 2015-02-17
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