CGS 15943CAS: 104615-18-1
MF: C13H8ClN5O
MW: 285.69
A potent Adenosine A Receptor antagonist.

CGS 15943 (CAS 104615-18-1)

CGS 15943 | CAS 104615-18-1 is rated 5.0 out of 5 by 1.
  • y_2020, m_1, d_25, h_20
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.4
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_203544, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 140ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: 9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
Application: A potent Adenosine A Receptor antagonist
CAS Number: 104615-18-1
Purity: ≥99%
Molecular Weight: 285.69
Molecular Formula: C13H8ClN5O
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

CGS 15943 is a potent, non-selective Adenosine A Receptor antagonist. It is orally active in vivo.


References

1. Williams, M., et al. 1987. J. Pharmacol. Exp. Ther. 241: 415-420. PMID: 2883298
2. Ghai, G., et al. 1987. J. Pharmacol. Exp. Ther. 242: 784-790. PMID: 3656113
3. Klotz, K.N. 2000. Naunyn Schmiedebergs Arch. Pharmacol. 362: 382-391. PMID: 11111832

Physical State :
Solid
Solubility :
Soluble in DMSO (>10 mg/ml). Insoluble in water.
Storage :
Store at room temperature
Melting Point :
272-273° C
Boiling Point :
467.62° C (Predicted)
Density :
~1.7 g/cm3 (Predicted)
Refractive Index :
n20D 1.84 (Predicted)
IC50 :
Adenosine A2a receptor: IC50 = 2.8 nM (Rattus norvegicus); Adenosine A1 receptor: IC50 = 6 nM (Rattus norvegicus); Adenosine A2a receptor: IC50 = 3.3 nM (Rattus norvegicus); Adenosine A2b receptor: IC50 = 2.8 nM (Rattus norvegicus); Cavia porcellus: IC50 = 3 nM
Ki Data :
A1 receptors: Ki= 3.5 nM (human); A2A receptors: Ki= 4.2 nM (human); A2B receptors: Ki= 16 nM (human); A3 receptors: Ki= 51 nM (human)
pK Values :
pKb: 0.93
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
XZ6157954
PubChem CID :
2690
MDL Number :
MFCD01529897
SMILES :
C1=COC(=C1)C2=NN3C(=N2)C4=C(C=CC(=C4)Cl)N=C3N

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

CGS 15943  Product Citations

See how others have used CGS 15943. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 27510152  Liu, C.|Skaldin, M.|Wu, C.|Lu, Y.|Zavialov, AV.| et al. 2016. Sci Rep. 6: 31370.

PMID: # 27624155  Pougnet, JT. et al. 2016. Sci Rep. 6: 31836.

Citations 1 to 2 of 2 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 102ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Ghai et al Ghai et al. (PubMed ID 3656113) found that CGS 15943 inhibited 2-chloroadenosine-induced decreases in diastolic blood pressure in rats. -SCBT Publication Review
Date published: 2015-02-09
  • y_2020, m_1, d_25, h_20
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.4
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_203544, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 11ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.