CGH 2466An Adenosine A1-R, Adenosine A2B-R, Adenosine A3-R, and p38 inhibitor

CGH 2466 (CAS 1177618-54-0)

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Synonym: 4-(3,4-Dichlorophenyl)-5-(4-pyridin yl)-2-thiazolamine dihydrochloride
Application: An Adenosine A1-R, Adenosine A2B-R, Adenosine A3-R, and p38 inhibitor
CAS Number: 1177618-54-0
Purity: >99%
Molecular Weight: 395.13
Molecular Formula: C14H9N3SCl2.2HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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CGH 2466 is an Adenosine A1-R, Adenosine A2B-R and Adenosine A3-R antagonist (IC50 values are 19, 21, and 80 nM respectively). CGH 2466 also inhibits p38 MAPK (IC50 = 187-400 nM) and PDE4 (phosphodiesterase type 4D) (IC50 = 22 nM).


References

1. Trifilieff, A., et al. 2005. Br. J. Pharmacol. 144: 1002-1010. PMID: 15685201

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mM), and ethanol (5 mM).
Storage :
Desiccate at 4° C
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
Adenosine A1-R: IC50 = 19 nM; Adenosine A2B-R : IC50 = 21 nM; PDE4D: IC50 = 22 nM; Adenosine A3-R: IC50 = 80 nM; p38: IC50 = 187 - 400 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5282339
MDL Number :
MFCD08703116
SMILES :
C1=CC(=C(C=C1C2=C(SC(=N2)N)C3=CC=NC=C3)Cl)Cl

Download SDS (MSDS)

Certificate of Analysis

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