CFTR Inhibitor-172A voltage-independent inhibitor of CFTR

CFTR Inhibitor-172 (CAS 307510-92-5)

CFTR Inhibitor-172 | CAS 307510-92-5 is rated 5.0 out of 5 by 1.
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Synonym: 3-[(3-Trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone; 4-[4-Oxo-2-thioxo-3-(3-trifluoromethyl-phenyl)-thiazolidin-5-ylidenemethyl]-benzoic acid;
Application: A voltage-independent inhibitor of CFTR
CAS Number: 307510-92-5
Purity: ≥95%
Molecular Weight: 409.40
Molecular Formula: C18H10F3NO3S2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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CFTR Inhibitor-172 is a voltage-independent inhibitor of CFTR hloride channel blocker (Ki = 300 nM). CFTR Inhibitor-172 is also shown to block intestinal fluid secretion that is cholera toxin-induced.


References

Yang, H., et al. 2003. J. Biol. Chem. 278, 35079. Al-Awqati, Q., et al. 2002. J. Clin. Invest. 110, 1599. Ma, T., et al. 2002. J. Clin. Invest. 110, 1651.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
254.02° C (Predicted)
Boiling Point :
555.71° C at 760 mmHg (Predicted)
Density :
1.61 g/cm3 (Predicted)
Refractive Index :
n20D 1.70 (Predicted)
IC50 :
CFTR: IC50 = 300 nM (human)
Ki Data :
CFTR chloride channel: Ki= 300 nM
pK Values :
pKa: 3.71 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
1554208
MDL Number :
MFCD06411408
SMILES :
C1=CC(=CC(=C1)N2C(=O)/C(=C/C3=CC=C(C=C3)C(=O)O)/SC2=S)C(F)(F)F

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Certificate of Analysis

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CFTR Inhibitor-172  Product Citations

See how others have used CFTR Inhibitor-172. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 27827428  Fujii, S. et al. 2016. Sci Rep. 6: 36795.

PMID: # 26965147  Hayashi, M. et al. 2016. Pflugers Arch.

PMID: # 25587116  Greenlee, MM. et al. 2015. Am. J. Physiol. Renal Physiol. 308: F697-705.

PMID: # 24793242  Joseph, EK. et al. 2014. J Pain. 15: 771-7.

PMID: # 18314534  Chen, L. et al. 2008. Am. J. Respir. Cell Mol. Biol. 39: 150-162.

PMID: # 17519339  Xu, WM. et al. 2007. Proc. Natl. Acad. Sci. USA. 104: 9816-9821.

Citations 1 to 6 of 6 total
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Rated 5 out of 5 by from Chen Chen, L. et al. (PubMed 18314534) demonstrated that nitric oxide (NO) stimulation of Calu-3 cells caused an increase in short-circuit current via indirect activation of CFTR. Introduction of the CFTR inhibitor-172 significantly reversed the NO increased short-circuit currents. -SCBT Publication Review
Date published: 2015-07-16
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