cFMS Receptor Inhibitor IV is a cell-permeable furan carboxamide compound that acts as a potent, reversible, and ATP-competitive c-Fms-CSF-1R (cFMS/CSF-1R) inhibitor. cFMS Receptor Inhibitor IV blocks cFMS autophosphorylation in cell-free in vitro kinase assays and in CSF-1/M-CSF-stimulated HEK-293 cells.
1. Patch, Raymond J., et al., 2007. Potent 2'-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents. Bioorganic & medicinal chemistry letters. 17(22): 6070-4. PMID: 17904845
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