cFMS Receptor Inhibitor IVA cell-permeable furan carboxamide compound

cFMS Receptor Inhibitor IV (CAS 959626-45-0)

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Synonym: CSF-1 Receptor Inhibitor IV
Application: A cell-permeable furan carboxamide compound
CAS Number: 959626-45-0
Molecular Weight: 378.47
Molecular Formula: C22H26N4O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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cFMS Receptor Inhibitor IV is a cell-permeable furan carboxamide compound that acts as a potent, reversible, and ATP-competitive c-Fms-CSF-1R (cFMS/CSF-1R) inhibitor. cFMS Receptor Inhibitor IV blocks cFMS autophosphorylation in cell-free in vitro kinase assays and in CSF-1/M-CSF-stimulated HEK-293 cells.


References

1. Patch, Raymond J., et al., 2007. Potent 2'-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents. Bioorganic & medicinal chemistry letters. 17(22): 6070-4. PMID: 17904845

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml).
Storage :
Store at -20° C
Boiling Point :
530.49° C at 760 mmHg (Predicted)
Density :
1.26 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
cFMS autophosphorylation: IC50 = 17 nM (cell-free in vitro kinase assays); cFMS autophosphorylation: IC50 = 76 nM (CSF-1/M-CSF-stimulated HEK-293 cells )
pK Values :
pKa: 10.55 (Predicted), pKb: 8.02 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
28408236
MDL Number :
MFCD10568148
SMILES :
C1CCN(CC1)C2=CC(=C(C=C2)N3CCCCC3)NC(=O)C4=CC=C(O4)C#N

Download SDS (MSDS)

Certificate of Analysis

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