Cevimeline-d4 Hydrochloride SaltA labeled muscarinic M1 and M3 receptor agonist

Cevimeline-d4 Hydrochloride Salt (CAS 107220-28-0 (unlabeled))

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Application: A labeled muscarinic M1 and M3 receptor agonist
CAS Number: 107220-28-0 (unlabeled)
Purity: ≥97%
Molecular Weight: 239.80
Molecular Formula: C10H14D4ClNOS
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cevimeline-d4 Hydrochloride Salt is a rigid analogue of acetylcholine which functions as a muscarinic M1 and M3 receptor agonist. This analogue functions by activating the acetylcholine receptors on salivary acinar cells. The effects of Cevimeline-d4 Hydrochloride Salt can be inhibited by atropine. Studies indicate that Cevimeline-d4 Hydrochloride Salt increases the intracellular concentration of calcium ions in vitro via binding to muscarinic receptors. Alternate studies show that Cevimeline-d4 Hydrochloride Salt can excite superior salivatory neurons via enhancement in excitability of the presynaptic and postsynaptic muscarinic receptors.


References

1. Wetter, L.A. and Way, L.W. 1991. Gastroenterol. Clin. North Am. 20: 157-169. PMID: 2022419
2. Weber, J. and Keating, G.M. 2008. Drugs. 68: 1691-1698. PMID: 18681491
3. Kondo, Y., et al. 2011. J Pharmacol Exp Ther. [Epub ahead of print]. PMID: 21239510

Physical State :
Solid
Solubility :
Soluble in Water
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
71434171
SMILES :
[2H]C1(OC2(CN3CCC2CC3)CS1)C([2H])([2H])[2H].Cl

Download SDS (MSDS)

Certificate of Analysis

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