CepharanthineA biscoclaurine alkaloid that has antiinflammatory and other biological functions

Cepharanthine (CAS 481-49-2)

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Synonym: Cepharanthin; O-Methylcepharanoline
Application: A biscoclaurine alkaloid that has antiinflammatory and other biological functions
CAS Number: 481-49-2
Purity: ≥95%
Molecular Weight: 606.71
Molecular Formula: C37H38N2O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cepharanthine is a biscoclaurine alkaloid with antiinflammatory, antiallergic, immunomodulatory, antiangiogenic, apoptosis inducing, and antiviral properties. Cepharanthine has also been shown to inhibit tumor necrosis factor α (TNF-α) mediated NFKB stimulation, and inhibits HIV-1 entry and cell fusion by decreasing plasma membrane fluidity.


References

Koji Harada, Tarannum Ferdous, Yasutaka Itashiki, Michiyo Takii, Takamichi Mano, Yoshihide Mori, Yoshiya Ueyama, International Journal of Oncology (2009) 35; 1025-35. Kondo, Y., Takano, F., Hojo, H. Biochem. Pharmacol. 46:1887-1892 (1993). Okamoto, M.,

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in organic solvents, DMSO (100 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C). Insoluble in petroleum ether.
Storage :
Store at -20° C
Melting Point :
143-152° C
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 0.23 µM (Plasmodium falciparum); MCF7: IC50 = 2.9 µM (human); SW480: IC50 = 4.7 µM (human); A549: IC50 = 5 µM (human); HL-60: IC50 = 9.2 µM (human)
Ki Data :
Trypanothione reductase: Ki= 7.6 µM
pK Values :
pKb: 6.25
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
FK0527000
PubChem CID :
10206
Merck Index :
12: 2031
MDL Number :
MFCD00210482
SMILES :
CN1CCC2=CC3=C(C4=C2[C@@H]1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)C[C@@H]7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3

Download SDS (MSDS)

Certificate of Analysis

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Cepharanthine  Product Citations

See how others have used Cepharanthine. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28923401  Lyu, J. et al. 2017. Cancer Lett. 409: 91-103.

Citations 1 to 1 of 1 total
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