Celastrol, Celastrus scandens, a compound originally purified from Tripterygium wilfordii, has been shown to be an anti-peroxidative and anti-angiogenic agent. Mechanistic studies suggest that Celastrol suppresses levels of VEGF and Flk-1 receptors, VEGFR-1 and VEGFR-2, which may reduce signal transduction between the two growth factors. Additionally, Celastrol has demonstrated the ability to disrupt critical interaction of Glu33 (Hsp90) and Arg167 (Cdc37) in the superchaperone complex which causes anti-proliferative activity in vitro and inhibit Topo II (topoisomerase II) activity in vitro (IC50 = 7.41 μM). Celastrol, Celastrus scandens is an inhibitor of Hsp90.
1. Sassa, H., et al. 1990. Biochem. Biophys. Res. Commun. 172: 890-897. PMID: 2241977 2. Huang, Y., et al. 2008. Cancer Lett. 264: 101-106. PMID: 18343027 3. Zhang, T., et al. 2008. Mol. Cancer Ther. 7: 162-170. PMID: 18202019
Soluble in DMSO (>10 mg/ml), ethanol, DMF:PBS(pH 7.2)(1:10), and DMF. Insoluble in water.
Do you know if heating the compound affects its activity? I heated a new stock (approx 50 deg C) that I received to try to dissolve it in DMSO and found it to be less efficacious compared to an older stock.
Asked by: AlexP
Thank you for your question. Heating for some time may affect its activity. This product should be soluble in DMSO (>10 mg/ml), ethanol, DMF:PBS(pH 7.2)(1:10), and DMF. It is insoluble in water. Please reach out to Technical service if you need further assistance with this biochemical.
Answered by: Tech Service
Date published: 2019-10-14
What is the appearance of the compound?
Asked by: two2igm05
Thank you for your question. The compound, sc-3508, is provided as a red powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing firstname.lastname@example.org, or using the Live Chat function on our website.
Rated 5 out of
TrottTrott, A. et al. (PubMed 18199679) studied the biological effects of Celastrol (Celastrus scandens), a compound that displays anti-peroxidative, anti-angiogenic, and anti-proliferative properties. They found that Celastrol inhibited glucocoritcoid receptor activity and that its effects could be blocked by the addition of excess free thiol. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.Hide
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.