Celastrol, Celastrus scandensAn antiproliferative, antipreroxidative, and inhibits Topo II

Celastrol, Celastrus scandens (CAS 34157-83-0)

Celastrol, Celastrus scandens | CAS 34157-83-0 is rated 5.0 out of 5 by 1.
  • y_2019, m_10, d_17, h_19
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202534, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 120ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: Tripterine
Application: An antiproliferative, antipreroxidative, and inhibits Topo II
CAS Number: 34157-83-0
Purity: ≥98%
Molecular Weight: 450.61
Molecular Formula: C29H38O4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Celastrol, Celastrus scandens, a compound originally purified from Tripterygium wilfordii, has been shown to be an anti-peroxidative and anti-angiogenic agent. Mechanistic studies suggest that Celastrol suppresses levels of VEGF and Flk-1 receptors, VEGFR-1 and VEGFR-2, which may reduce signal transduction between the two growth factors. Additionally, Celastrol has demonstrated the ability to disrupt critical interaction of Glu33 (Hsp90) and Arg167 (Cdc37) in the superchaperone complex which causes anti-proliferative activity in vitro and inhibit Topo II (topoisomerase II) activity in vitro (IC50 = 7.41 μM). Celastrol, Celastrus scandens is an inhibitor of Hsp90.


References

1. Sassa, H., et al. 1990. Biochem. Biophys. Res. Commun. 172: 890-897. PMID: 2241977
2. Huang, Y., et al. 2008. Cancer Lett. 264: 101-106. PMID: 18343027
3. Zhang, T., et al. 2008. Mol. Cancer Ther. 7: 162-170. PMID: 18202019

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (>10 mg/ml), ethanol, DMF:PBS(pH 7.2)(1:10), and DMF. Insoluble in water.
Storage :
Store at 4° C
Melting Point :
219-230° C
Boiling Point :
~645.7° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.6 (Predicted)
IC50 :
IL-1β and IL-1α: IC50 = 40 nM; IL-6: IC50 = 80 nM; PGE2: IC50 = 110 nM; IL-8 and TNF-α: IC50 = 210 nM; LPS-induced NF-κB activation: IC50 = 270 nM; NO production: IC50 = 230 nM (RAW264.7 cells); lipid peroxidation induced by ADP and Fe2+: IC50 = 7 µM (rat liver mitochondria ); Plasmodium falciparum (isolate K1 / Thailand): IC50 = 0.18 µg/ml (Plasmodium falciparum K1); HT-29 (Colon adenocarcinoma cells): IC50 = 1.3 µg/ml (Homo sapiens); Heat shock factor protein 1: EC5050 = 1100 nM (Homo sapiens)
Ki Data :
: Ki= 4200 nM
pK Values :
pKa: 4.78
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
PubChem CID :
122724
MDL Number :
MFCD03424073
SMILES :
CC1=C(C(=O)C=C2C1=CC=C3[C@]2(CC[C@@]4([C@@]3(CC[C@@]5([C@H]4C[C@](CC5)(C)C(=O)O)C)C)C)C)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Celastrol, Celastrus scandens  Product Citations

See how others have used Celastrol, Celastrus scandens. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 19916747  Zhu, H. et al. 2010. Cancer Invest. 28: 23-32.

PMID: # 18199679  Trott, A. et al. 2008. Mol. Biol. Cell. 19: 1104-1112.

PMID: # 17223266  Paris, D. et al. 2007. Neurosci. Lett. 415: 11-16.

PMID: # 16984800  Lee, JH. et al. 2006. Biochem. Pharmacol. 72: 1311-1321.

PMID: # 2241977  Sassa, H. et al. 1990. Biochem. Biophys. Res. Commun. 172: 890-897.

Citations 1 to 5 of 5 total

Do you know if heating the compound affects its activity? I heated a new stock (approx 50 deg C) that I received to try to dissolve it in DMSO and found it to be less efficacious compared to an older stock.

Asked by: AlexP
Thank you for your question. Heating for some time may affect its activity. This product should be soluble in DMSO (>10 mg/ml), ethanol, DMF:PBS(pH 7.2)(1:10), and DMF. It is insoluble in water. Please reach out to Technical service if you need further assistance with this biochemical.
Answered by: Tech Service
Date published: 2019-10-14

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-3508, is provided as a red powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-17
  • y_2019, m_10, d_17, h_19CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_en_US, sid_202534, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 105ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Trott Trott, A. et al. (PubMed 18199679) studied the biological effects of Celastrol (Celastrus scandens), a compound that displays anti-peroxidative, anti-angiogenic, and anti-proliferative properties. They found that Celastrol inhibited glucocoritcoid receptor activity and that its effects could be blocked by the addition of excess free thiol. -SCBT Publication Review
Date published: 2015-04-01
  • y_2019, m_10, d_16, h_19
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202534, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 109ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.