cDPCPA tumor cell permeable, potent platinum-based antineoplastic agent

cDPCP (CAS 106343-54-8)

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Synonym: Pyriplatin
Application: A tumor cell permeable, potent platinum-based antineoplastic agent
CAS Number: 106343-54-8
Purity: ≥98%
Molecular Weight: 379.14
Molecular Formula: C5H11Cl2PtN3
* Refer to Certificate of Analysis for lot specific data (including water content).
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cDPCP is a tumor cell permeable, potent platinum-based antineoplastic agent. cDPCP is a cationic monofunctional platinum(II) complex with unique chemical and biological properties. cDPCP binds covalently to only a single DNA base (the N7 atom of a single guanosine residue), and forms monofunctional rather than bifunctional lesions in DNA.


References

Lovejoy, K. S. et al., cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects Proc. Natl. Acad. Sci. USA 105, 8902-8907, (2008); Hollis, L.S., et al,, Chemical and biological properties of a new series of cis-diammineplatinum(II) antitumor agents containing three nitrogen donors: cis-[Pt(NH3)2(N-donor)Cl] J. Med. Chem. 32, 128-136, (1989)

Physical State :
Solid
Solubility :
Soluble in Water: >10 mg/mL
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
PubChem CID :
44277023
SMILES :
C1=CC=NC=C1.N.N.[Cl-].Cl[Pt]

Download SDS (MSDS)

Certificate of Analysis

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