CDKN2AIP Antibody (18.7): sc-81841

CDKN2AIP Antibody (18.7) is a mouse monoclonal IgG1 kappa light chain antibody that detects CDKN2AIP protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-CDKN2AIP antibody (18.7) is available as the non-conjugated format. CDKN2AIP, also known as CARF, plays a crucial role in regulating the cell cycle by activating the tumor suppressor protein p53 through both p14 ARF-dependent and independent pathways. This activation is vital as p53 is responsible for inducing growth arrest and apoptosis in response to cellular stress, thereby preventing the proliferation of potentially cancerous cells. Expression levels of CDKN2AIP and p53 are inversely related, a relationship maintained by a negative-feedback mechanism involving proteasome-mediated degradation. CDKN2AIP is ubiquitously expressed across various tissues and is localized to the perinucleolar region within the nucleus, where CDKN2AIP interacts directly with MDM2, a key regulator of p53. This interaction not only represses MDM2 transcription but also leads to CDKN2AIP′s degradation via the MDM2-dependent proteasome pathway. Notably, CDKN2AIP contains a double-stranded RNA-binding domain, indicating potential involvement in post-transcriptional gene regulation, which may further influence cellular responses to stress and the overall integrity of the cell cycle.

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CDKN2AIP Antibody (18.7) References:

1. CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53.  |  Hasan, MK., et al. 2002. J Biol Chem. 277: 37765-70. PMID: 12154087
2. Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control.  |  Hasan, MK., et al. 2004. Biochem J. 380: 605-10. PMID: 15109303
3. CARF regulates p19ARF-p53-p21WAF1 senescence pathway by multiple checkpoints.  |  Kaul, SC., et al. 2006. Ann N Y Acad Sci. 1067: 217-9. PMID: 16803988
4. CARF binds to three members (ARF, p53, and HDM2) of the p53 tumor-suppressor pathway.  |  Kamrul, HM., et al. 2007. Ann N Y Acad Sci. 1100: 312-5. PMID: 17460193
5. CARF (collaborator of ARF) interacts with HDM2: evidence for a novel regulatory feedback regulation of CARF-p53-HDM2-p21WAF1 pathway.  |  Hasan, MK., et al. 2008. Int J Oncol. 32: 663-71. PMID: 18292944

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CDKN2AIP Antibody (18.7) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-CDKN2AIP Antibody (18.7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CDKN2AIP Antibody (18.7) Specifications

Alternate Product Name: CDKN2AIP

Product Clone Name: 18.7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-580

Epitope Target: CDKN2AIP

Epitope Species: human

Product Reactivity/Detection: CDKN2AIP

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for CDKN2AIP Antibody (18.7): N/A