Cdk4 Inhibitor III CAS: 265312-55-8
MF: C15H12N2O2S
MW: 284.33
A cell-permeable, selective Cdk4 inhibitor.

Cdk4 Inhibitor III (CAS 265312-55-8)

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Alternate Names: Ryuvidine; 2-methyl-5-(p-tolylamino)benzo[d]thiazole-4,7-dione
Application: Cdk4 Inhibitor III is a cell-permeable, selective Cdk4 inhibitor
CAS Number: 265312-55-8
Purity: ≥98%
Molecular Weight: 284.33
Molecular Formula: C15H12N2O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cdk4 Inhibitor III is a cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC50 = 6.0 mM for Cdk4/D1 and > 200 mM for Cdk2/A). Cdk4 Inhibitor III exhibits better cytotoxic potential against cancer cells (IC50 = 0.61, 1.08, 0.30, and 1.21 mg/ml against A 549, Col 1, HepG2 tumor cells, respectively) than Cisplatin.


References

Ryu, C.K., et al. 2000. Bioorg. Med. Chem. Lett. 10, 461.

Physical State :
Solid
Solubility :
Soluble in DMSO (50 mM), and ethanol (5 mM).
Storage :
Store at 4° C
Melting Point :
187.14° C (Predicted)
Boiling Point :
~463.78° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.71 (Predicted)
IC50 :
HL-60: IC50 = 0.3 nM (human); A549: IC50 = 0.61 nM (human); COLO1: IC50 = 1.08 nM; Cdk4: IC50 = 6 nM (human); Cdk2: IC50 >200 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD09971103
SMILES :
CC1=CC=C(C=C1)NC2=CC(=O)C3=C(C2=O)N=C(S3)C

Download SDS (MSDS)

Certificate of Analysis

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Cdk4 Inhibitor III (CAS 265312-55-8)  Product Citations

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PMID: # 27192561  2016. Cell Cycle. 15: 1787-95.

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