Cdk2/9 InhibitorCAS: 507487-89-0
MF: C14H12N6O2S
MW: 328.34
A cell-permeable aminopyrimidinyl compound.

Cdk2/9 Inhibitor (CAS 507487-89-0)

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Synonym: 4-methyl-5-[2-(3-nitroanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine
Application: A cell-permeable aminopyrimidinyl compound
CAS Number: 507487-89-0
Molecular Weight: 328.34
Molecular Formula: C14H12N6O2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cdk2/9 Inhibitor is a cell-permeable aminopyrimidinyl compound that acts as a potent and ATP-competitive inhibitor of Cdk2/E and Cdk9/T1. Also inhibits GSK-3β, Cdk4/D, Cdk7/H, Cdk1/B, and Abl at higher concentrations, but exhibits little activity towards 9 other kinases. Cdk2/9 Inhibitor has been shown to inhibit phosphorylation of cellular Cdk substrates, pRb and RNA polymerase II, and Cdk2-mediated S-phase transition.


References

1. Wang, Shudong., et al., 2004. 2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity. Journal of medicinal chemistry. 47(7): 1662-75. PMID: 15027857
2. Kontopidis, George., et al., 2006. Differential binding of inhibitors to active and inactive CDK2 provides insights for drug design. Chemistry & biology. 13(2): 201-11. PMID: 16492568

Physical State :
Solid
Solubility :
Soluble in DMSO
Storage :
Store at 4° C
Melting Point :
223.09° C (Predicted)
Boiling Point :
~590.5° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
447961
SMILES :
CC1=C(SC(=N1)N)C2=NC(=NC=C2)NC3=CC(=CC=C3)[N+](=O)[O-]

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Cdk2/9 Inhibitor  Product Citations

See how others have used Cdk2/9 Inhibitor. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27378523  Chen, Z. et al. 2016. Sci Rep. 6: 29090.

Citations 1 to 1 of 1 total
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