Cdk1/5 Inhibitor is a 3-amino substituted pyrazoloquinoxaline compound that acts as a selective inhibitor of Cdk1 and Cdk5 (IC50 = 600 nM for Cdk1/cyclin B and 400 nM for Cdk5/p25. Cdk1/5 Inhibitor is also shown to inhibit GSK-3β with (IC50 > 10 μM). Cdk1/5 Inhibitor does not inhibit Cdc25 phosphatase activity (IC50 > 10 μM).
1. Ortega, Miguel A., et al., 2002. Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors. Bioorganic & medicinal chemistry. 10(7): 2177-84. PMID: 11983514
See how others have used Cdk1/5 Inhibitor (CAS 40254-90-8). Click on the entry to view the PubMed entry .
PMID: # 27378523 Chen, Z. et al. 2016. Sci Rep. 6: 29090.
PMID: # 25013173 Bounedjah, O. et al. 2014. Nucleic Acids Res. 42: 8678-91.