Cdk1/5 Inhibitor is a 3-amino substituted pyrazoloquinoxaline compound that acts as a selective inhibitor of Cdk1 and Cdk5 (IC50 = 600 nM for Cdk1/cyclin B and 400 nM for Cdk5/p25. Cdk1/5 Inhibitor is also shown to inhibit GSK-3β with (IC50 > 10 μM). Cdk1/5 Inhibitor does not inhibit Cdc25 phosphatase activity (IC50 > 10 μM).
1. Ortega, Miguel A., et al., 2002. Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors. Bioorganic & medicinal chemistry. 10(7): 2177-84. PMID: 11983514
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