CDC25 Phosphatase Inhibitor I, BN82002CAS: 396073-89-5
MF: C19H25N3O4
MW: 359.4
A cell-permeable ortho-hydroxybenzylamino compound.

CDC25 Phosphatase Inhibitor I, BN82002 (CAS 396073-89-5)

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Synonym: 4-(dimethylamino)-2-methoxy-6-[[methyl-[2-(4-nitrophenyl)ethyl]amino]methyl]phenol
Application: A cell-permeable ortho-hydroxybenzylamino compound
CAS Number: 396073-89-5
Molecular Weight: 359.4
Molecular Formula: C19H25N3O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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CDC25 Phosphatase Inhibitor I, BN82002, is a cell-permeable ortho-hydroxybenzylamino compound that has been reported to display antitumor properties. It has been shown to act as a potent, selective and irreversible inhibitor of the CDC25 phosphatase family (IC50 = 2.4, 3.9, 6.3, 5.4, and 4.6 µM for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). Reported to display a ~20-fold greater selectivity for CDC25 phosphatases over CD45 tyrosine phosphatase. Also shown to delay cell cycle progression in vitro (IC50 = ~7.2-32.6 µM), and reduces tumor growth in athymic mice xenografted with the human pancreatic cells MIA PaCa-2 (15 mg/kg, i.p. route).


1. Brezak, Marie-Christine., et al., 2004. A novel synthetic inhibitor of CDC25 phosphatases: BN82002. Cancer research. 64(9): 3320-5. PMID: 15126376

Physical State :
Solubility :
DMSO and ethanol
Storage :
Store at -20° C
Melting Point :
86-88° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :

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