Cdc2 p34 Antibody (F-5) is a mouse monoclonal IgG3 κ, cited in 3 publications, provided at 200 µg/ml
specific for an epitope mapping between amino acids 42-57 within the conserved PSTAIRE domain of Cdc2 p34 of human origin of Cdc2 p34 of human origin
recommended for detection of Cdc2 p34 and other kinases containing the PSTAIRE and PFTAIRE motifs of mouse, rat, human, chicken and avian origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
See Cdc2 p34 (17): sc-54 for Cdc2 p34 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Cdc2 p34 Antibody (F-5). This work is in progress.
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In vertebrates, as in yeast, multiple cyclins have been identified, including a total of eight such regulatory proteins in mammals. In contrast to the situation in yeast, the Cdc2 p34 kinase is not the only catalytic subunit identified in vertebrates that can interact with cyclins. While Cdc2 p34 is essential for the G2 to M transition in vertebrate cells, a second Cdc2-related kinase has also been implicated in cell cycle control. This protein, designated cyclin-dependent kinase 2 (Cdk2) p33, also binds to cyclins and its kinase activity is temporally regulated during the cell cycle. Several additional Cdc2 p34-related cyclin dependent kinases have been identified. These include Cdk3-Cdk8, PCTAIRE-1-3 and KKIALRE.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.