Anti-CD45R Antibody (RA3-6B2) is a rat monoclonal IgG2aCD45R antibody, cited in 24 publications, provided at 200 µg/ml
Anti-CD45R Antibody (RA3-6B2) is recommended for detection of CD45R of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM
Anti-CD45R Antibody (RA3-6B2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to either APC-Cy7 or PerCP for IF, IHC(P) and FCM
also provided azide-free for modulation of B-cell responses in vitro and in vivo, sc-19597 L, 200 µg/0.1 ml
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of CD45R (RA3-6B2): sc-19597.
At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD45R Antibody (RA3-6B2). This work is in progress.
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Labware ships FedEx Ground free of charge to the contiguous US
CD45R Antibody (RA3-6B2) is a high quality monoclonal CD45R antibody (also designated CD45 antibody, PTPRC antibody or protein tyrosine phosphatase receptor type C antibody) suitable for the detection of the CD45R protein of mouse, rat and human origin. CD45R Antibody (RA3-6B2) is available as both the non-conjugated anti-CD45R antibody form, as well as multiple conjugated forms of anti-CD45R antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphotyrosine phosphatase, a vital component for efficient tyrosine phosphorylation induction by the TCR/CD3 complex. The tyrosine phosphatase activity of CD45R is contained within the conserved intracellular domain. Src and Syk family protein tyrosine kinases are utilized by the TCR/CD3 complex to initiate signaling cascades. Several members of these two families, including Lck, Fyn and ZAP-70, have been implicated as physiological substrates of CD45R.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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