Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Semaphorins comprise a family of phylogenetically conserved proteins containing a 500 amino acid region termed the "Sema domain" in the amino-terminus. The semaphorin family is subdivided into eight groups. CD100 (SEMA4D) is a transmembrane protein belonging to group IV of the semaphorin family. CD100 is expressed in both embryonic and adult kidney, heart, lung and neural tissues. Plexin-B1, a receptor expressed abundantly in fetal brain and kidney, binds CD100 with high affinity. CD100 is the only member of the semaphorin family that is expressed in the immune system. CD100 activates T cell proliferation and promotes B cell aggregation. CD100 regulates B cell response by negating an inhibitory signal from CD72 that normally diminishes B cell response. This signal is turned off when CD100 binds to CD72 and induces tyrosine dephosphorylation of CD72, followed by the dissociation of SHP-1 from CD72. The gene encoding human CD100 maps to chromosome 9q22-q31.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.